Clinical and Patient-Reported Outcomes in Patients With and Without Severe Bradykinesia According to Sensor Measurements
Objective: To explore clinical and patient-reported outcomes in patients with and without severe sensor-measured bradykinesia in patients with Parkinson’s disease (PD). Background: Parkinson's disease (PD)…Effects of Rhythmic Auditory Stimulation Combined with LSVT BIG based exercises and Task-Specific Training on Balance and Gait in Parkinson Disease
Objective: To examine the effects of RAS combined with LSVT-BIG based exercises and TST on balance, fall risk, functional mobility, posture and gait parameters in…The Spectrum of Praxis Impairments in Patients with Parkinson’s Disease
Objective: Our study aims to examine the state of praxis within the structure of motor impairments in patients with Parkinson's disease (PD). Background: PD is…The “Guarda” (Tower) Drawing Test: A Novel Bedside Tool to Quantify Bradykinesia in Parkinson’s Disease
Objective: Quantify Bradykinesia Through Standardized Drawing in PD patients. Background: Bradykinesia is the cardinal symptom in Parkinson's Disease (PD). The slowing and progressive reduction in…Basal Ganglia Pathway Recruitment Determines Bidirectional Bradykinesia Modulation by DBS in Humans
Objective: Understanding the role of distinct basal ganglia pathways in DBS-elicited modulation of bradykinesia across its indications. Background: Opposing bidirectional effects of selective pathway stimulation…Digital Kinematic Measures of Finger Tapping Detect Dose-Dependent Effects of Deep Brain Stimulation in Parkinson’s Disease
Objective: To evaluate whether video-based digital kinematic measures can quantify dose-dependent changes in finger tapping performance during deep brain stimulation (DBS) in Parkinson’s disease. Background:…The Lentiform Fork Sign: Acute Parkinsonism in a Dialysis Patient with Metformin Misuse
Objective: To report a rare case of the Lentiform Fork Sign associated with acute parkinsonism in a patient with end-stage renal disease and metformin-associated lactic acidosis. Background: The Lentiform Fork Sign is a rare neuroradiological finding characterized by bilateral T2/FLAIR hyperintensities in the basal ganglia outlining the internal and external capsules (1). It has been most commonly described in patients with end-stage renal disease and is typically associated with metabolic acidosis. The proposed mechanism involves cerebral acidosis leading to vasogenic and/or cytotoxic edema in metabolically vulnerable regions such as the basal ganglia (2). Method: We report a 43-year-old man with end-stage renal disease on hemodialysis and type 2 diabetes mellitus who presented with…Differential effects of levodopa and subthalamic nucleus deep brain stimulation on the bradykinesia components in Parkinson’s Disease
Objective: To quantify and compare the differential effects of DBS and L-dopa on the individual kinematic components of bradykinesia. Background: Parkinson’s disease (PD) bradykinesia is…Can Prayer Beads Quantify Bradykinesia? An Ultra-Low-Cost Approach to Motor Assessment in Parkinson’s Disease
Objective: To explore the potential use of portable mechanical counters as a simple approach to quantifying finger movement activity in the evaluation of bradykinesia. Background:…Microstructural Correlates of Parkinson’s Bradykinesia
Objective: Define the microstructural correlates of bradykinesia in Parkinson’s disease. Background: Bradykinesia is defined as “slowness of movement”, often associated with decrement, and linked to…
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