Parkinson’s-disease risk variants are differentially associated with discrete phenotypic characteristics of Parkinson’s-disease at baseline.
Objective: Evaluate whether genetic risk variants for Parkinson’s disease discovered in case-control GWAS uniformly or differentially contribute to the clinical phenotype of PD. Background: Genetic…Kinematic assessment of bradykinesia in patients with amyotrophic lateral sclerosis
Objective: To kinematically assess abnormalities of voluntary upper limbs movements in patients with amyotrophic lateral sclerosis compared to healthy subjects. To investigate possible relationships between…Movement Disorders Analysis Using a Deep Learning Approach
Objective: Using a deep learning inspired approach, we developed a tool to compute an objective score of bradykinesia. Background: Bradykinesia is defined as a motor…Patient experience interviews to inform a digital assessment of Parkinson’s disease
Objective: The aim of this study is to generate a conceptual framework that maps patient-relevant functional limitations to behavioral measures that can be captured with…A New Web-Based Tapping Test for Measuring Distal Bradykinesia in Parkinson’s Disease
Objective: 1. To develop a web-based test that objectively measures distal bradykinesia, 2. To validate the test by assessing PD patients and healthy controls, and…Robotic Assisted Arm Training in Parkinson’s disease rehabilitation: A pilot study
Objective: The aim and objective of this study was to evaluate whether robotic assisted arm training might improve upper limb function in patients with Parkinson’s…Inertial sensor-based kinematics in the differential diagnosis of Parkinson’s disease and atypical parkinsonisms
Objective: Assess the role of inertial sensors in the phenotyping and differential diagnosis of Parkinson’s Disease vs. Atypical Parkinsonisms Background: Wearable devices have been used…White Matter Changes and Early Cognitive Impairment in Parkinson’s Disease
Objective: Studying white matter changes in Parkinson's disease patients using diffusion tensor imaging; and its relation to cognition and motor symptoms impairment. Background: Cognitive dysfunction…Real-World Evidence for a Smartwatch-based Parkinson’s Motor Assessment App in Patients Undergoing Therapy Changes
Objective: We sought to investigate patient and clinician usability of a smartwatch-based wearable motor assessment system for measuring Parkinson’s disease (PD) motor symptoms in patients undergoing…Compartment-specific blockade of dopamine uptake in nigrostriatal pathway reveals role for nigral dopamine function in movement frequency in open-field
Objective: Inhibition of tyrosine hydroxylase activity in the substantia nigra (SN) produces a significant reduction in locomotor motor activity commensurate with decreased dopamine (DA) content…
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