Prasinezumab reduced progression of Parkinson’s disease motor features measured by Roche PD Mobile Application v2 sensor features: PASADENA Phase II Part 1
Objective: To determine whether digital biomarker sensor data detect slowing in progression of core motor features of Parkinson’s disease (PD) in individuals with early PD…Early-onset vs. Late-onset Parkinson’s disease
Objective: To determine the clinical and therapeutic peculiarities that distinguish Early onset Parkinson’s disease (EOPD) from late onset Parkinson’s disease (LOPD). Background: Age is the…“Striatal Hand Signs” and early diagnosis of Parkinson’s Disease: The “Monkey-Wrench Sign”.
Objective: To identify signs of hand deformations in PD patients with earlier diseases, and compare with intermediate and late phases patients. Background: “Striatal hand signs”,…Parkinson’s-disease risk variants are differentially associated with discrete phenotypic characteristics of Parkinson’s-disease at baseline.
Objective: Evaluate whether genetic risk variants for Parkinson’s disease discovered in case-control GWAS uniformly or differentially contribute to the clinical phenotype of PD. Background: Genetic…Motor Function Test Protocol for Parkinsonian Triad in Rodent Model of Parkinson’s Disease
Objective: To review motor deficits protocols and create a set of behavioural protocols that critically address the parkinsonian triad's quantification in Parkinson's disease models. Background:…Longitudinal Speech Changes In PD and the Relationship to Limb Bradykinesia and Rigidity
Objective: We tested the assumption that speech diadochokinesis (DDK) in Parkinson’s disease (PD) parallels motor system performances by evaluating DDK changes over 12-months and testing if DDK performance predicts limb bradykinesia and rigidity UPDRS scores. Background: Studies showing that speech DDK correlates with…‘Asymmetric thumb-index angle’ in PD: A new observation in an old disease
Objective: To report a novel sign on inspection in PD that is present throughout different dopaminergic states Background: Inspection is arguably one of the most…Wearable Devices in Movement Disorder Trials to Provide Objective Measures
Objective: To understand the validity of wearable devices in capturing objective motor and nonmotor symptoms of Parkinson’s Disease (PD) in addition to what has been…Compartment-specific blockade of dopamine uptake in nigrostriatal pathway reveals role for nigral dopamine function in movement frequency in open-field
Objective: Inhibition of tyrosine hydroxylase activity in the substantia nigra (SN) produces a significant reduction in locomotor motor activity commensurate with decreased dopamine (DA) content…Smartphone-based context awareness to improve ambulatory Parkinson’s monitoring
Objective: To determine the utility of context-awareness algorithms based on sensors in smartphones to improve ambulatory Parkinson’s disease (PD) monitoring. Background: Previous research shows that optimal motion sensor-based ambulatory PD monitoring requires multiple sensors to…
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