MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Calcium"

  • 2023 International Congress

    Quantitative investigation of the pathway between dopamine receptors and Ca2+ channels in layer II stellate cells towards Parkinson’s disease

    C. Mahapatra, A. Pradhan (MUMBAI, India)

    Objective: Recent experimental data suggest a putative coupling between dopamine D2 receptors (D2R) and T-type Ca2+ channels as another biophysical explanation for the firing pattern…
  • 2023 International Congress

    Impaired CaMKII/ERK activation in mouse mutant LRRK2 R1441G fibroblasts was associated with reduced mitochondrial calcium store and efflux in response to depolarization stress

    E. Chang, Y. Malki, Z. Choi, H. Liu, S. Zhang, S. Pang, M. Kung, D. Ramsden, S. Ho, P. Ho (Hong Kong, Hong Kong)

    Objective: To determine the molecular link of LRRK2R1441G mutation to impaired CaMKII/ERK signaling under mitochondrial depolarization stress using mutant mouse embryonic fibroblast (MEF) model of…
  • 2023 International Congress

    Autosomal recessive Primary Familial Brain Calcification caused by MYORG mutations. Two unrelated cases from the south of Chile

    E. Fernandez, P. Meza, P. Saffie (Concepción, Chile)

    Objective: To describe two unrelated cases of AR- PFBC with mutations in MYORG gene. Background: Primary Familial Brain Calcification (PFBC) is a rare neurogenetic disorder…
  • 2023 International Congress

    Design of a Phase 2 Study of Suvecaltamide in Moderate to Severe Parkinson’s Disease Tremor

    R. Hauser, C. Adler, G. Deuschl, M. Baladi, P. Chandler, T. Skarpass, K. Xu, P. Lewitt (Tampa, USA)

    Objective: Describe the design of a phase 2 study (NCT05642442) of a once-daily, extended-release formulation of suvecaltamide to treat moderate to severe Parkinson’s disease tremor…
  • 2023 International Congress

    Bone Health in Parkinson’s Disease

    E. Killeen, C. Gallagher, A. Mcdonough (Dublin, Ireland)

    Objective: Optimise bone health in people with Parkinson’s Disease Background: People with Parkinson’s Disease (PD) have an increased risk of osteoporosis and associated fractures due…
  • 2023 International Congress

    Exome sequencing of 584 Chinese proband with brain calcification

    ZR. Lin (Hangzhou, China)

    Objective: The aim of this study is to evaluate the diagnostic value of whole exome sequencing in Chinese patients with brain calcification, and to provide exome sequencing-based insights into the genetic…
  • 2023 International Congress

    Calcium phenotype in cellular models of VPS13A disease

    E. Fischer, K. Peikert, A. Spranger, H. Glaß, D. Großmann, A. Hermann (Rostock, Germany)

    Objective: Since the Membrane contact sites (MCS) between ER and mitochondria are of particular importance for cellular calcium homeostasis, we hypothesize that MCS dysfunction in…
  • 2022 International Congress

    In Silico Study Reveals Cocaine Exposure Modulates Dopamine Neuron Firing Patterns by Inhibiting Small Conductance Calcium Activated Potassium Current

    CHI. Mahapatra (Mumbai, India)

    Objective: The neurological reason behind the loss of dopamine neurons causing Parkinson’s disease (PD) is an unsolved mystery. Background: As PD is identified as a…
  • 2022 International Congress

    Symptomatic brain calcifications in two patients with JAM2 monoallelic variants.

    S. Andretta, G. Bonato, M. Mainardi, L. Salviati, A. Antonini, M. Carecchio (Padova, Italy)

    Objective: To describe two subjects carrying monoallelic JAM2 genetic variant associated with brain calcification. Background: Primary Familial Brain Calcification (PFBC) is a rare neurodegenerative disorder…
  • MDS Virtual Congress 2021

    Cognitive profiling in a cohort of Primary Familial Brain Calcification (PFBC) patients

    M. Garon, M. Carecchio, L. Weis, F. Pistonesi, M. Mainardi, G. Bonato, L. Salviati, A. Antonini, R. Biundo (Padova, Italy)

    Objective: To investigate neuropsychological and behavioural profile of PFBC patients. Background: PFBC is a rare genetic neurodegenerative disorder characterized by abnormal calcium phosphate deposition basal…
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