Cerebellar Network Compensation in Parkinson’s Disease: Functional Connectivity Across Motor and Cognitive Circuits
Objective: To investigate whether alterations in cerebellar connectivity with cortical and basal ganglia networks in Parkinson’s disease (PD) represent compensatory network adaptations related to dopaminergic…Multiple System Atrophy-India (MSA-IND) Registry
Objective: To understand Multiple system atrophy (MSA) clinical phenotype from India. Background: There is paucity of data from underrepresented populations including India, regarding the clinical…Accessible Assessment of Ataxia Severity Across Diverse Populations: Integrating Large Datasets, Machine-Learning, and Online Testing
Objective: To explore whether internet-based assessments combined with machine learning approaches can support scalable characterization of ataxia severity. Background: In-person assessments of ataxia severity are…Cerebellar-cortical-spinal information flow for motor kinematic control
Objective: If M1 generates final motor outputs and cerebellar temporal kinematic information must pass through M1, then M1 should relay cerebellar frequency codes to the…Cerebellar-Basal Ganglia Circuitry in the Pathogenesis of Parkinsonian Postural Instability
Objective: To elucidate the role of impaired interactions between the basal ganglia and the cerebellum in the PI development in PD patients. Background: Postural instability…Clinical Gait Traits and Cerebellar-PPN Functional Connectivity Abnormalities in Early and Moderate-to-Advanced PD with Gait Disturbance via Perceptual Technology and MRI
Objective: To investigate clinical gait characteristics and cerebellar-pedunculopontine nucleus (PPN) functional connectivity (FC) changes in early-stage and moderate-to-advanced-stage Parkinson’s disease (PD) with gait disturbance using wearable…Frequency and Phenotypic Characterization of Genetic Causes of Sporadic Late-Onset Cerebellar Ataxia: insights from a Cohort of 315 patients
Objective: To estimate the prevalence, characterize the phenotypic spectrum, identify discriminative features of genetically determined SLOCA and implement a machine learning model for rationalizing SLOCA…Clinical Spectrum of Cerebellar Fits in Adults and Children: A Systematic Review
Objective: To systematically review the clinical characteristics, etiological associations, electroencephalographic findings, management strategies, and outcomes of cerebellar fits across pediatric and adult populations. Background: Cerebellar…Cerebellar peduncle microstructure and autonomic dysfunction in Parkinson’s disease
Objective: To investigate whether cerebellar peduncle microstructure is associated with autonomic dysfunction in Parkinson’s disease (PD). Background: Autonomic dysfunction is a common and disabling non-motor…Does CANVAS mimic MSA-C
Objective: To describe the natural history of RFC1-related ataxia, identify discriminative features compared to MSA-C, and study their survival outcomes. Background: AAGGG intronic expansions in…
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