The Presence of Efferent Brain-Gut Neuropathy Correlates with Severe Constipation in Parkinson’s disease
Objective: We aim to correlate brain-gut neuropathy amongst cortico- and lumbosacro-anorecal efferent pathways in PD subjects with severe constipation measured by prospective stool diary. Background:…Intestinal transit in early-moderate Parkinson’s disease correlates with probable RBD – subclinical esophageal dysmotility does not correlate
Objective: To investigate esophageal and intestinal transit times in early-moderate Parkinson's disease (PD) and to study correlations with probable RBD and subjective symptoms. Background: Intraneuronal…The Gut Dysmotility Questionnaire (GDQ) for Parkinson’s disease: current development
Objective: To develop a questionnaire to screen for and monitor gastrointestinal symptoms in patients with Parkinson’s disease (PD), entitled Gut Dysmotility Questionnaire (GDQ). Background: Gut…Path to Prevention (P2P) – Developing a Prodromal PD Progression Biomarker Program
Objective: The overall objective of the Path to Prevention (P2P) initiative is to identify clinical, imaging, and biologic markers of progression during the prodromal phase…The Dutch Parkinson and Microbiome Study (DUPARM): Gut Microbiome Composition of Treatment-Naïve De Novo Parkinson’s Disease Patients
Objective: To establish the gut microbiome composition of de novo Parkinson’s disease (PD) patients with no history of dopaminergic medication use. Background: PD is often…Comprehensive clinico-pathophysiological assessment of constipation in Parkinson’s disease
Objective: To perform a comprehensive assessment of constipation in Parkinson’s disease (PD) using various complementary diagnostic techniques to elucidate its pathophysiology and improve its symptomatic…The ultrasonographic assessment of vagus nerve atrophy comparison with autonomic dysfunction in Parkinson’s disease
Objective: To investigate the relationship between vagus nerve atrophy and clinical manifestation in Parkinson’s disease (PD). Background: PD is the progressive neurodegenerative disease and causes…Evaluation of Constipation in Patients with Parkinson’s Disease and its Correction
Objective: To evaluate the possible causes of constipation, and to find clear methods to correct the disorder. Background: Constipation is a common problem in Parkinson's…Intestinal nerve damage and gut dysfunction in mouse models of Parkinson’s Disease
Objective: This work aims to investigate gut dysfunction and enteric neuropathy in several mouse models of PD to provide insight into enteric nervous system (ENS)…Functional Bowel Symptoms in Parkinson´s Disease
Objective: We assessed the prevalence of functional bowel disorders in patients with Parkinson´s disease (PD) using Rome III criteria. Background: A significant fraction of PD…
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