The Presence of Efferent Brain-Gut Neuropathy Correlates with Severe Constipation in Parkinson’s disease
Objective: We aim to correlate brain-gut neuropathy amongst cortico- and lumbosacro-anorecal efferent pathways in PD subjects with severe constipation measured by prospective stool diary. Background:…Intestinal transit in early-moderate Parkinson’s disease correlates with probable RBD – subclinical esophageal dysmotility does not correlate
Objective: To investigate esophageal and intestinal transit times in early-moderate Parkinson's disease (PD) and to study correlations with probable RBD and subjective symptoms. Background: Intraneuronal…The Gut Dysmotility Questionnaire (GDQ) for Parkinson’s disease: current development
Objective: To develop a questionnaire to screen for and monitor gastrointestinal symptoms in patients with Parkinson’s disease (PD), entitled Gut Dysmotility Questionnaire (GDQ). Background: Gut…Functional Bowel Symptoms in Parkinson´s Disease
Objective: We assessed the prevalence of functional bowel disorders in patients with Parkinson´s disease (PD) using Rome III criteria. Background: A significant fraction of PD…MIBG myocardial scintigraphy identifies premotor PD/DLB during a negative DAT scan period
Objective: It is unknown which marker is useful to identify the premotor phase PD/DLB. We recently reported four patients who, during a negative DAT scan…Characteristics of lower gastrointestinal tract dysfunction in patients with Parkinson disease
Objective: To evaluate the characteristics of lower gastrointestinal tract dysfunction in patients with Parkinson disease (PD). Background: Lower gastrointestinal tract dysfunction is common in patients…Characterization of the gastrointestinal dysfunction in the 6-hydroxydopamine rat model of Parkinson’s disease
Objective: To characterize the gastrointestinal (GI) phenotype in the 6-hydroxydopamine (6OHDA) rat model of Parkinson’s disease (PD). Background: GI dysfunction, such as prolonged GI transit…A Prospective Study of the Effects of Deep Brain Stimulation on Constipation and Olfaction in Parkinson Disease
Objective: To investigate the effects of subthalamic nucleus deep brain stimulation (STN-DBS) on constipation and olfaction in patients with Parkinson disease (PD). Background: STN-DBS is…Gastrointestinal microbiome in Parkinson’s disease in a Bavarian cohort
Objective: Our goal was to evaluate, whether gut microbiota are altered in a Southern German PD cohort. In addition, we assessed changes in the microbiome…Path to Prevention (P2P) – Developing a Prodromal PD Progression Biomarker Program
Objective: The overall objective of the Path to Prevention (P2P) initiative is to identify clinical, imaging, and biologic markers of progression during the prodromal phase…
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