MIBG myocardial scintigraphy identifies premotor PD/DLB during a negative DAT scan period
Objective: It is unknown which marker is useful to identify the premotor phase PD/DLB. We recently reported four patients who, during a negative DAT scan…Characteristics of lower gastrointestinal tract dysfunction in patients with Parkinson disease
Objective: To evaluate the characteristics of lower gastrointestinal tract dysfunction in patients with Parkinson disease (PD). Background: Lower gastrointestinal tract dysfunction is common in patients…Characterization of the gastrointestinal dysfunction in the 6-hydroxydopamine rat model of Parkinson’s disease
Objective: To characterize the gastrointestinal (GI) phenotype in the 6-hydroxydopamine (6OHDA) rat model of Parkinson’s disease (PD). Background: GI dysfunction, such as prolonged GI transit…A Prospective Study of the Effects of Deep Brain Stimulation on Constipation and Olfaction in Parkinson Disease
Objective: To investigate the effects of subthalamic nucleus deep brain stimulation (STN-DBS) on constipation and olfaction in patients with Parkinson disease (PD). Background: STN-DBS is…Gastrointestinal microbiome in Parkinson’s disease in a Bavarian cohort
Objective: Our goal was to evaluate, whether gut microbiota are altered in a Southern German PD cohort. In addition, we assessed changes in the microbiome…A randomized double-blind placebo-controlled trial of probiotics for constipation in Parkinson’s disease
Objective: To investigate the effects of probiotics on constipation in PD, using a randomized controlled trial (RCT) design Background: Non-motor symptoms (NMS) cause significant disability…The Gut Microbiota in a Canadian Parkinson’s Disease Cohort
Objective: To compare the gut microbiota between PD patients and matched controls in a Canadian cohort and to examine correlations between microbes and disease parameters…Characterization of the gastrointestinal dysfunction in mice overexpressing the human mutation (A53T) of alpha-synuclein
Objective: The aim of this study was to determine if mice overexpressing the human mutation of alpha-synuclein develop gastrointestinal (GI) dysfunction, and to understand the…Striatal dopamine transporter availability changes reflect gastrointestinal dysautonomia severity in early Parkinson’s disease
Objective: To test the hypothesis that constipation and gastrointestinal (GI) dysautonomia may be correlated with nigrostriatal dopaminergic (DA) dysfunction in PD. Background: Constipation is a…Early gastrointestinal dysfunction is predictive of faster progression in Parkinson’s disease
Objective: To evaluate whether constipation at time of diagnosis has prognostic significance in terms of motor and cognitive progression in PD. Background: There is evidence…
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