Expanding Diversity of Parkinson’s Disease and Related Disorders Genetic Data: from the Global Parkinson’s Genetics Program
Objective: To expand the research dataset for Parkinson’s Disease (PD) and related disorders by including >50,000 participants globally who have been genotyped or whole genome…Sex Differences for Regional Lewy Body Pathology in Pathologically-Defined Lewy Body Dementia
Objective: To investigate sex differences for regional Lewy body (LB) pathology burden, and regional LB pathology association with clinical diagnosis across people with a high…Baseline and Longitudinal NSD-ISS Staging of the PPMI Cohort
Objective: To apply biological definition and Neuronal α-Synuclein Disease Integrated Staging System (NSD-ISS) to the PPMI baseline and longitudinal dataset. Background: The NSD-ISS Working Group…The Pro-LBD Study Investigating Early Detection, Prognosis, and Biomarkers of Prodromal Lewy Body Diseases
Objective: The Pro-LBD cohort study is a prospective, long-term, clinic-biological cohort study of participants who are stratified by their risk of developing a Lewy body…Prodromal dementia with Lewy bodies in REM sleep behavior disorder: A multicenter study
Objective: To assess the progression and predictive value of neuropsychological testing on the development of dementia in idiopathic REM sleep behavior disorder (iRBD). Background: iRBD…Sleep seasonality in alpha-synucleinopathies: a comparative study with non-neurological sleep disorder patients
Objective: To assess month of the year related changes in polysomnography (PSG) data in patients with alpha-synucleinopathies. Background: Season of the year related changes in…Longitudinal free-water changes in dementia with Lewy bodies
Objective: To characterize longitudinal diffusion microstructural changes in individuals with dementia with Lewy bodies (DLB). Background: Diffusion-weighted MRI (dMRI) examines tissue microstructure integrity in vivo.…T1 MRI reveals differential hippocampal atrophy in Lewy body disorders with and without Alzheimer’s copathology
Objective: Determine whether MRI can identify differences in hippocampal volume between patients with Lewy body disorders with and without Alzheimer's copathology, and whether these differences…Topography of cholinergic vulnerability correlates of PIGD motor deficits in DLB and PSP: A [18F]-FEOBV PET study
Objective: To understand the relationship between cholinergic vulnerability and Postural Instability and Gait Disturbances (PIGD) motor features in dementia with Lewy bodies (DLB), and progressive…RT-QuIC for detection of pathological α-synuclein in the olfactory mucosa and CSF of Parkinson’s disease patients
Objective: To investigate the proficiency of RT-QuIC in detecting the presence of misfolded α-synuclein (α-syn) on the olfactory mucosa (OM) and CSF of patients with…
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