Aberrant connectivity in Resting-State Brain Networks Underlying Neuropsychiatric Symptoms in Prodromal Lewy Body Dementia.
Objective: This study aimed to determine the functional neural correlates of neuropsychiatric symptoms (NPS), including mood disorders, anxiety and psychosis, in prodromal Lewy body dementia (LBD)…Utilization of Skin Punch Biopsy for the Diagnosis of Alpha-synucleinopathy in Clinical Practice
Objective: To understand the use of skin punch biopsies for diagnosis and management of α-synucleinopathy within a large medical system. Background: Skin punch biopsy has…Predictors of Death within 6 Months in Individuals with Dementia with Lewy Bodies
Objective: To assess predictors of death in the subsequent 6 months in dementia with Lewy bodies (DLB). Background: Individuals with DLB commonly die of disease-related…Cardiovascular Associations of Cortical Lewy Bodies in the Oldest Old: The 90+ study
Objective: To identify potential risk factors for cortical Lewy Bodies (CLB) in the oldest-old (> 90 years old), we investigated if cardiovascular medical histories, medication…A Randomized, Double-blind, Phase 2a Clinical Trial to Study the Efficacy and Safety of Lamotrigine for Treatment of Patients with Dementia with Lewy Bodies
Objective: This proof-of-concept clinical trial will test the efficacy and safety of lamotrigine compared to placebo in patients with dementia with Lewy bodies (DLB). Background:…Assessing the Accuracy of Clinical Diagnostic Criteria of Lewy Body Dementia for Detection of Lewy Body Disease in the Oldest-Old: The 90+ Study
Objective: To examine if Lewy Body dementia (LBD) clinical diagnostic criteria will be less accurate for detecting Lewy Body Disease (the pathological diagnosis) in the oldest-old…Exploring the Therapeutic Target for Lewy Body Disease using gba1 Knock-out Medaka
Objective: This study was performed to explore the therapeutic target for Lewy body disease. Background: Lewy body disease (LBD), including Parkinson's disease and diffuse Lewy…Accuracy of Clinical features for Substantia Nigra Hypopigmentation and Cortical Lewy Body Presence in the Oldest-Old: The 90+ Study
Objective: To improve clinical diagnostic accuracy of Lewy Body Dementia (LBD), we assessed if frontal release signs are a useful screening tool for cortical Lewy…Diffusion MRI and Machine Learning Distinguish Alzheimer’s Disease and Dementia with Lewy Bodies
Objective: This study reports recent updates in the development of a support vector machine learning model to discriminate between dementia variants (i.e., Alzheimer’s disease (AD)…Association between environmental phthalates exposure and gut microbiota and metabolome in dementia with Lewy bodies
Objective: We examined the association between environmental phthalates (PAEs) exposure and gut microbiota and metabolome in dementia with Lewy bodies (DLB). Background: Alongside genetic factors,…
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