Data-driven Longitudinal Trajectories of Hippocampal Volume in Parkinson’s Disease and Across the Neurodegenerative Disease Spectrum
Objective: To elucidate hippocampal (HP) volume trajectories in Parkinson disease (PD) and across the neurodegenerative disease (NDD) spectrum. Background: HP volume is a critical neuroimaging…Optimizing Institutional Long-Term Care in Advanced Parkinson’s and Other Neurodegenerative Disease: The OPTICARE Study
Objective: To analyze and improve institutional long-term care (LTC) structures for patients with advanced PD and AD by identifying modifiable determinants of care integration, QoL,…The Burden of Cognitive Impairment in People with Parkinson’s across Outpatients and Prevalent Patients in Coastal Kenya: A Transforming Parkinson’s Care in Africa (TraPCAf) Study
Objective: To describe the rate and severity of cognitive impairment within the coastal Kenyan cohort of TraPCAf. Background: Cognitive impairment is a well-recognised non-motor symptom of PD, however there is very…Spatiotemporal Trajectories of Plasma Biomarkers and Diffusion MRI Metrics in Parkinson’s Disease
Objective: To investigate the spatiotemporal dynamics of multimodal biomarkers and their role in early prediction of cognitive decline. Background: Cognitive impairment is a major source…Investigating the Link Between Alzheimer’s Disease Genetic Risk Variants and Parkinson’s Disease Cognitive Impairment: An Exploration of Genetic Overlap
Objective: To investigate whether variants from a large Alzheimer’s disease (AD) genome-wide association study (GWAS; Bellenguez et al. 2022) in Europeans - including 85,934 clinically…The Evolutionary Pathway of Cognitive Impairment in Parkinson’s Disease: A SuStaIn Study
Objective: We aim to characterize the evolution and subtypes in the cognitive impairment in Parkinson’s disease (PD). Background: Cognitive impairment (CI) is one of the…Shunt‑Responsive Normal Pressure Hydrocephalus in Spinocerebellar Ataxia Type 12: A Case Illustrating Treatable Neurodegenerative Overlap
Objective: To report a rare coexistence of normal pressure hydrocephalus (NPH) in a patient with genetically confirmed spinocerebellar ataxia (SCA) type 12 and present a…Baseline plasma neurofilament light and phosphorylated tau 181 levels predict longitudinal cognitive decline in APOE4 and long SNCA Rep1 carriers in Parkinson’s disease
Objective: Plasma neurofilament light (NfL; a marker of axonal injury) and phosphorylated tau 181 (pTau181) are biomarkers that have been associated with cognitive decline in…Normative Data for the IDEA Dementia Screen in Healthy Older Adults and People with Parkinson’s Disease in Ethiopia: A Comparative Cross Sectional Study
Objective: This study aims to establish Ethiopian normative data for IDEA in healthy older adults and People with Parkinson's disease, and to evaluate its appropriateness…Longitudinal cognitive trajectories and predictors of dementia conversion in Parkinson’s disease
Objective: To determine clinical predictors of longitudinal cognitive decline and dementia conversion in a real-world Parkinson’s disease (PD) cohort. Background: Cognitive impairment is one of…
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