Early life stress offers a window into the relationship between depression and Parkinson’s disease: A 60-week study after maternal separation in rats
Objective: The aim of this study was to examine the relationship between depression and Parkinson's disease (PD) using the rat model of maternal separation (MS).…The Personalized Parkinson Project – data quality enhancing strategies
Objective: Demonstrate the impact of quality enhancing strategies in the Personalized Parkinson Project. Background: Increasingly, the scientific community uses data from longitudinal observational patient cohorts…Clinical outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency (PTPSd)
Objective: To assess morbility and clinical outcome of patients affected by defect of tetrahydrobiopterin (BH4) synthesis due to PTPSd. Background: PTPSd is a treatable genetic disorder…Loss‐of‐function mutations in NR4A2 cause dopa‐responsive dystonia-parkinsonism
Objective: To report two patients with early-onset dystonia-parkinsonism as a result of loss-of-function mutations in nuclear receptor subfamily 4 group A member 2 (NR4A2). Background:…Usability assessments in patients with Parkinson’s disease: The foundation for a holistic telemedical solution (TelePark)
Objective: The TelePark project has the objective to develop a holistic telemedicine platform for patients with Parkinson’s disease. For a successful implementation, it is necessary…Automated Capture of Deep Brain Stimulation Settings & Clinical Outcomes
Objective: To automate capture of deep brain stimulation (DBS) settings and clinical outcomes during programming for movement disorders. Background: DBS programming involves testing a wide…Feasibility of a simplified, symptom-based electronic diary to improve evaluation of motor and non-motor complications in Parkinson’s disease
Objective: To determine the feasibility of the simplified and symptom-based electronic PD diary and compare with the standard paper diary. Background: Motor complications (MC) is…Evaluation of nigral neuronal apoptosis during postnatal development and adulthood of mice strains with differential sensitivity to MPTP
Objective: Compare nigral neurons in C57BL/6J, CD-1 and their F1 crossbreds with respect to developmental apoptosis in the nigra during postnatal and to assess MPTP-induced…Gender-dependent improvement in the survival of Parkinson’s disease patients in Finland
Objective: To longitudinally investigate the overall survival (OS) of a large cohort of Parkinson's disease (PD) patients. Background: While there is evidence of increasing incidence,…Laboratory Performance of the DopaFuse® Delivery System
Objective: SynAgile has developed the DopaFuse Delivery System to noninvasively and continuously administer levodopa/carbidopa (LD/CD) into the mouths of patients with Parkinson’s Disease (PD). The…
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