Reduced vesicular storage of catacholamines enhance MPTP-induced death of dopaminergic neurons in locus coeruleus and olfactory bulb
Objective: In this study, we employed heterozygous knockout (vmat2+/-) mice to investigate the influence of reduced vesicular storage of catacholamines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-impaired dopaminergic neurons…Neuroprotective effect of α-Mangostin in restoration mitochondrial function in MPTP-Induced Parkinson’s disease in mice
Objective: The aim of the present study was to explore the protective effect of alpha-mangostin against mitochondrial oxidative stress in MPTP treated mice. Background: It…Neuroactive steroids reverse the dopaminergic neurotransmission defectiveness in chronic hepatic (HE) encephalopathy: a possible involvement in HE related parkinsonism
Objective: In the present study, we describe the changes of the dopaminergic system occurring in the cirrhotic rats and concomitantly we investigated the effect of…Personal KinetiGraph Devices Assessing Efficacy of Continuous Enteral Carbidopa/Levodopa Infusion Therapy
Objective: To assess the utility of Personal KinetiGraph (PKG) devices to objectively quantify difference in motor symptoms and motor fluctuations before and after the initiation…Lifetime exposure to estrogen and risk for progressive supranuclear palsy
Objective: To investigate the protective effect of estrogen on progressive supranuclear palsy (PSP). Background: Animal and human epidemiologic studies of Parkinson’s disease and Alzheimer’s dementia have…Intracerebroventricular administration of dopamine: A new therapeutic concept for Parkinson’s disease?
Objective: In this study, we aim to demonstrate that continuous i.c.v. infusion of dopamine close to the striatum is a feasible and highly efficient treatment…Impact of levodopa-induced dyskinesias on Health-related Quality of Life. Results from the French COPARK study.
Objective: To assess the impact of LIDs on HRQoL in this large sample of unselected Parkinson’s Disease (PD) patients and to assess the factors related…Serum vitamin B12 levels in patients with Parkinson’s disease and its association with peripheral neuropathy and cognition
Objective: To compare serum Vitamin B12 levels among PD patients and normal controls and to assess the association of Vitamin B12 levels with various disease parameters, peripheral…Pharmaeconomic study of the treatment of advanced Parkinson’s disease.
Objective: Conduct a comparative pharmacoeconomic analysis of the use of subcutaneous apomorphine infusion pump (SAIP), continuous levodopa/carbidopa duodenal infusión (LDI) and deep brain stimulation (DBS). Background:…Curcumin I protect against copper induced neurobehavioral features of Parkinson’s disease in rat
Objective: evaluate the impact of acute Cu intoxication (10 mg/kg B.W. i.p) for 3 days on the dopaminergic system and locomotor performance, together with the…
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