Delayed-Onset Rapidly Progressive Parkinsonism After BCMA×CD3 Bispecific Antibody Therapy: A Case Report
Objective: To describe a delayed-onset rapidly progressive parkinsonian syndrome with encephalopathy following BCMA×CD3 bispecific antibody therapy. Background: B-cell maturation antigen (BCMA) × CD3 bispecific antibodies…Parkinsonism in B-Cell Maturation Antigen-Targeting CAR-T Cell Cancer Therapies
Objective: Describe parkinsonism after B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR) T-cell therapy for treatment of multiple myeloma. Background: BCMA-targeted CART-cell therapy effectively treats…Late Diagnosed Kufor Rakeb Syndrome Presenting as Drug Induced Parkinsonism
Objective: Kufor-Rakeb syndrome (KRS) may present with a wide variety of psychiatric symptoms. This case describes the development of parkinsonism after antipsychotic treatment and the…Methanol Intoxication Presenting as a Mixed Ataxic-Parkinsonian Syndrome With a Paradoxical Response to Levodopa: A Case Report
Objective: To report a case of methanol-induced mixed cerebellar and parkinsonian sequelae, emphasizing the pathophysiological mechanisms underlying the neuroimaging findings and the paradoxical response to…Comparison of Motor Severity in Individuals with Drug-Induced Parkinsonism and Idiopathic Parkinson’s Disease A Systematic Review and Meta-Analysis
Objective: To compare motor severity between individuals with drug-induced Parkinsonism (DIP) and idiopathic Parkinson’s disease (iPD) Background: DIP and iPD may present with similar motor…Neuroprotective Effects of Emodin Against Rotenone-Induced Parkinsonism Through Regulation of SIRT1-Mediated Inflammasome and Nrf2 Pathways
Objective: This study aimed to investigate the neuroprotective potential of emodin in a rotenone-induced PD model and to elucidate its underlying molecular mechanisms focusing on…PEST-PD: Preliminary Findings from an Ongoing Longitudinal Observational Study for Prodromal Parkinson’s disease in farmers exposed to pesticides.
Objective: To compare the risk for prodromal Parkinson's disease (PD) in subjects exposed and non-exposed to pesticides Background: Farmers may have an elevated risk of…The Lentiform Fork Sign: Acute Parkinsonism in a Dialysis Patient with Metformin Misuse
Objective: To report a rare case of the Lentiform Fork Sign associated with acute parkinsonism in a patient with end-stage renal disease and metformin-associated lactic acidosis. Background: The Lentiform Fork Sign is a rare neuroradiological finding characterized by bilateral T2/FLAIR hyperintensities in the basal ganglia outlining the internal and external capsules (1). It has been most commonly described in patients with end-stage renal disease and is typically associated with metabolic acidosis. The proposed mechanism involves cerebral acidosis leading to vasogenic and/or cytotoxic edema in metabolically vulnerable regions such as the basal ganglia (2). Method: We report a 43-year-old man with end-stage renal disease on hemodialysis and type 2 diabetes mellitus who presented with…Baclofen-Induced Worsening of Parkinsonism in a Patient with CADASIL and Brainstem Stroke
Objective: To report baclofen-associated worsening of parkinsonism in a patient with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and recent brainstem infarction,…Neuroprotective and Antiparkinsonian Effects of Green-Synthesized Silver Nanoparticles from Eclipta prostrata in a Haloperidol-Induced Murine Model
Objective: To evaluate the antiparkinsonian efficacy of silver nanoparticles synthesized from Eclipta prostrata (SEP) in a haloperidol-induced murine model of Parkinson's disease (PD). Background: Eclipta…
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