MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Experimental therapeutics"

  • 2018 International Congress

    Educating Movement Disorders through a web based counselling service in Mauritius

    M. Busgopaul (Port Louis, Mauritius)

    Objective: The provision of solutions and relevant information to the general public and mostly to young people is the way forward to help the elderly…
  • 2018 International Congress

    Neuroprotective effects of coffee ingredients against rotenone-induced neurodegeneration in parkinsonian model

    I. Miyazaki, N. Isooka, R. Kikuoka, K. Wada, Y. Kitamura, M. Asanuma (Okayama, Japan)

    Objective: In this study, we examined neuroprotective effects of coffee ingredients, caffeic acid (CA) and chlorogenic acid (CGA), against rotenone-induced neurodegeneration using primary cultured cells…
  • 2017 International Congress

    Disease-modification in Translational Models of Parkinson’s disease by the Rho Kinase Inhibitor Fasudil

    L. Tönges, L. Tatenhorst, J. Koch, T. Outeiro, M. Zweckstetter, M. Bähr, P. Lingor (Bochum, Germany)

    Objective: To evaluate the therapeutic potential of the Rho Kinase (ROCK) inhibitor Fasudil in translational models of Parkinson’s disease (PD).  Background: There is still a…
  • 2017 International Congress

    Intracerebroventricular administration of dopamine: A new therapeutic concept for Parkinson’s disease?

    C. LALOUX, F. GOUEL, C. LACHAUD, K. Timmerman, A. Jonneaux, C. Moreau, R. BORDET, J.-c. DEVEDJIAN, D. DEVOS (LILLE, France)

    Objective: In this study, we aim to demonstrate that continuous i.c.v. infusion of dopamine close to the striatum is a feasible and highly efficient treatment…
  • 2017 International Congress

    AAV-mediated over-expression of VEGF-B in PINK1 gene knockout rats increases striatal dopamine content

    T. Falk, M. Bartlett, D. Muller, B. Silashki, D. Farrell, K. Parent, M. Heien, S. Sherman (Tucson, AZ, USA)

    Objective: To evaluate overexpression of the neuroprotective vascular endothelial growth factor B (VEGF-B) in a genetic Parkinson’s disease (PD) model. Background: We have shown in…
  • 2017 International Congress

    Identification of a trehalose treatment regimen with potential to be translated into a therapeutic for the treatment of Parkinson’s disease

    J. Koprich, P. Howson, T. Johnston, M. Hill, P. Ravenscroft, J. Brotchie (Toronto, ON, Canada)

    Objective: To evaluate the preclinical efficacy of trehalose and to identify a dosing regimen that can be used to clinically evaluate trehalose as a disease-modifying therapy…
  • 2017 International Congress

    NS-PARK/FCRIN network, the French Clinical Research Network for Parkinson’s disease and Movement Disorders

    E. Dellapina, V. Chaigneau, F. Durif, J.-C. Corvol, O. Rascol, F. NS-PARK/FCRIN network (Toulouse, France)

    Objective: The objective of NS-PARK/FCRIN network (http://www.parkinson.network/) is to facilitate and stimulate clinical academic and industrial research in France in the field of Parkinson's disease…
  • 2017 International Congress

    Improving Racial and Ethnic Diversity in Parkinson`s Disease Clinical Trials

    S. Ray, A. Madan, D. Burdick, A. Griffith, P. Agarwal (Kirkland, WA, USA)

    Objective:  To identify and overcome challenges to recruiting minorities in Parkinson's Disease  experimental therapeutic trials. Background: Inadequate representation of ethnic and minority population poses substantial…
  • 2017 International Congress

    Sample size estimation for clinical trials in de novo Parkinson’s disease (PD): Results from the Parkinson’s Progression Markers Initiative (PPMI) Study

    T. Simuni, C. Caspell-Garcia, N. Seedorff, C. Coffey, S. Lasch, B. Mollenhauer, C. Tanner, K. Kieburtz, K. Marek (Chicago, IL, USA)

    Objective: To use clinical and biological data from PPMI to estimate sample size for disease modification studies in de novo PD  Background: One barrier to…
  • 2017 International Congress

    Drug utilization characteristics in individuals with early Parkinson’s disease interim analysis of the STEADY-PD III study

    S. Sharma, T. Simuni, B. Greco, K. Biglan, C. Tarolli, K. Hodgeman, D. Oakes, D. Penz (Rochester, NY, USA)

    Objective: To review symptomatic therapy (ST) utilization trends in individuals with early Parkinson’s disease (PD). Background: There are changing trends in ST utilization in early…
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