Qualification of Digital Endpoints of Function in Healthy Volunteers for Use in a Decentralized Natural History Study in Genetic Parkinson’s Disease (PD)
Objective: Our goal was to qualify digital and wearable devices to assess the Timed Up and Go (TUG) test and gait related parameters in healthy…Neuroimaging associations to gait impairments in progressive supranuclear palsy
Objective: The aim of this study was to determine how multimodal imaging biomarkers were related to abnormalities in three-dimensional motion-based gait and balance measurements in…DO FREEZING OF GAIT AND GAIT AUTOMATICITY IN PARKINSON’S DISEASE SHARE THE SIMILAR NEURAL SUBSTRATE?
Objective: To verify if freezing of gait (FOG) in Parkinson’s disease (PD) and gait automaticity share a similar neural substrate. Background: FOG in PD may…Structural and functional cerebellar alterations in Parkinson’s disease with postural instability and gait disorders
Objective: This study aimed at assessing structural and functional cerebellar alterations in Parkinson’s disease patients with postural instability and gait disorders (PD-PIGD). Background: Brain structures…Tractography Analysis of the Pedunculopontine Nucleus Correlates with Gait Impairment in Parkinson’s Disease
Objective: Our objective was to correlate pedunculopontine nucleus (PPN) connectivity with quantitative gait metrics in Parkinson’s disease (PD) using diffusion tensor imaging (DTI). Background: Gait…Longitudinal structural and functional brain alterations in Parkinson’s disease patients with freezing of gait
Objective: To investigate the cortical/subcortical grey matter (GM) changes and network functional alterations in PD-FoG patients, in PD developing FoG (PD-FoG-converters) and PD not developing…Brain activity of the emotional circuit in Parkinson’s disease patients with freezing of gait
Objective: The aim of this observational study was to assess brain functional MRI (fMRI) activity during a “FoG observation task” in PD-FoG patients relative to…Factors contributing to prefrontal cortical activity during walking and its response to dual-tasking in Parkinson’s disease
Objective: We examined the contribution of clinical, cognitive, and gait characteristics to prefrontal cortex (PFC) activity during walking and its response to dual-task in people…Decreased mesencephalic locomotor region activation explains loss of presynaptic inhibition during step initiation in people with Parkinson´s disease with freezing of gait
Objective: To investigate if decreased mesencephalic locomotor activation (MRL) activation during step initiation in an-event related fMRI protocol would explain the loss of presynaptic inhibition…FREEZESTEP = DALFLEX
Objective: Freezing of gait(FOG) is defined as a brief, episodic absence or marked reduction of forward progression of the feet despite the intention to walk.…
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