MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Inflammation"

  • 2018 International Congress

    A panel of CSF and plasma biomarkers reveals novel biological insights into atypical parkinsonian syndromes

    E. Jabbari, J. Woodside, N. Magdalinou, A. Lees, H. Zetterberg, H. (London, United Kingdom)

    Objective: Our study aims to identify diagnostic markers of atypical parkinsonian disorders that offer novel insights into these conditions. In particular, we wish to use…
  • 2018 International Congress

    Peripheral Inflammatory Mediators in Parkinson’s Disease – A Potential Biomarker

    K. Chatterjee, A. Roy, R. Banerjee, S. Halder, S. Choudhury, P. Basu, S. Shubham, H. Kumar (Kolkata, India)

    Objective: i.To determine if post-translationally modified phosphorylated α-synuclein levels are altered in the peripheral blood of Parkinson’s disease (PD) patients compared to control subjects. ii.To…
  • 2018 International Congress

    Evidence for dysregulation of inflammatory mechanisms involving the NF-κB complex in the living parkinsonian brain

    S. Benoit, H. Xu, R. Alexandrova, G. Kaur, B. Thiruvahindrapuram, M. Hebb (London, ON, Canada)

    Objective: Sequence RNA in cortical samples taken from living PD patients to detect significant differentially expressed genes (DEGs) and altered biological pathways when compared to…
  • 2018 International Congress

    Association between peripheral inflammation and DATSCAN data of the striatal nuclei in different motor subtypes of Parkinson Disease

    H. Sanjari Moghaddam, F. Ghazi Sherbaf, M H. Aarabi, M. Mojtahed Zadeh (Tehran, Islamic Republic of Iran)

    Objective: This work was designed to investigate peripheral inflammation in terms of Neutrophil-Lymphocyte ratio (NLR) concerning loss of dopaminergic uptake in caudate and putamen on…
  • 2018 International Congress

    Role of microglia in the transmission of α-syn-containing exosomes

    Y. Xia, G. Zhang, J. Huang, N. Xiong, K. Ma, X. Guo, F. Wan, L. Kou, S. Yin, T. Wang (Wuhan, China)

    Objective: we investigated the role of microglia in the transmission of α-syn-containing exosomes and offer a new insight into the mechanism of PD pathogenesis. Background:…
  • 2018 International Congress

    B lymphocytes may be protective in early Parkinson’s disease and in an animal model of dopaminergic cell death

    K. Scott, C. Williams-Gray, R. Wijeyekoon, S. Hayat, K. Hall, P. Tyers, R. Mathews, R. Barker, M. Clatworthy (Cambridge, United Kingdom)

    Objective: To investigate B lymphocyte phenotype and function in human PD and in an animal model of disease. Background: The clinical course in Parkinson’s disease…
  • 2018 International Congress

    Pharmacological modulation of lysosomal glucocerebrosidase activity in the Thy1-aSYN mouse model of Parkinson’s disease

    K. Belarbi, E. Cuvelier, H. Carrie, M.A. Bonte, W. Sibran, C. Leghay, J. Von Gerichten, V. Nordström, R. Sandhoff, T. Comptdaer, N. Jouy, E. Mutez, A. Destee, C. Pincon, B. Gressier, M.C. Chartier-Harlin (Lille, France)

    Objective: To study the pharmacological modulation of glucocerebrosidase activity in the Thy1-aSYN mouse model of Parkinson's disease (PD). Background: PD is a complex neurodegenerative disorder…
  • 2018 International Congress

    Nanoscale imaging reveals disorganization of the brain extracellular space in Lewy body-injected mice

    F. Soria, N. Danne, C. Paviolo, E. Doudnikoff, B. Dehay, L. Groc, L. Cognet, E. Bezard (Bordeaux, France)

    Objective: To explore the brain extracellular space and its matrix at a nanometric scale in a context of α-synuclein-induced neurodegeneration. Background: The extracellular space (ECS)…
  • 2018 International Congress

    Tetrahydroisoquinoline Molecule Identified in Traditional Ayurveda Medicine Modulates Inflammation in MPTP Mice

    R. Banerjee, R. Paidi, P. Jaisankar, K. Mohanakumar, S. Biswas (Kolkata, India)

    Objective: Potential ‘Anti-parkinsonian’ activity of a tetrahydroisoquinoline (TIQ) molecule of traditional ‘Ayurveda’ medicine was tested in a preclinical MPTP mice model for Parkinson’s disease (PD).…
  • 2018 International Congress

    Molecular immunological action and epigenetic modification of the human papillomavirus vaccination and associated neuropsychiatric side effects

    N. Kanzato, K. Nakachi, Y. Takahashi (Okinawa, Japan)

    Objective: To investigate the clinical manifestations of neuropsychiatric side effects after the Human papillomavirus (HPV) vaccine, and to investigate the immunological actions and epigenetic modification.…
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