Neuroinflammation and activation of Zif-268 in dyskinetic 6-OHDA-lesioned rats is counteracted by association of a 5-HT1A/1B receptor agonist and an A2A receptor antagonist
Objective: To evaluate whether an early treatment with the serotonin 5-HT1A/1B receptor agonist eltoprazine and the adenosine A2A receptor antagonist preladenant prevent the onset of…The contribution of cerebrovascular risk factors, metabolic and inflammatory changes to cognitive decline in Parkinson’s disease
Objective: To examine the contributions of systemic factors to clinically relevant cognitive decline in Parkinson’s disease (PD), we studied the impact of cardiometabolic and inflammatory…Serum Inflammatory Profile for the Discrimination of tremor severity in essential tremor
Objective: To establish the correlation between cytokines level in the serum of patients with ET and disease severity. Background: Essential tremor (ET) is the most…The interaction between iron metabolism and inflammation in Parkinson´s disease: an in vivo and post mortem study
Objective: To assess the relationship iron and inflammatory markers in an in vivo and post mortem study of Parkinson´s disease subjects. Background: Although neuroinflammation and…Blood Metagenomics Analyses of Brazilian Parkinson’s Disease Patients: A Clinical Substype Study
Objective: The goal of this study is to analyze the dormant microbiome present in blood of Parkinson’s disease (PD) patient and healthy controls samples by…7,8- Dihydroxyflavone prevents 3-NitropropionicAcid (3-NP)-induced Striatal Toxicity by Modulating the TrkB receptor and Microglial Activation Pathway
Objective: Hungtion’s disease (HD) is an autosomal governing neurodegenerative disorder caused by production of mutant hungtingtin(Htt) protein followed by death of the GABAergic neurons in…Functional Proteomic Analysis of Leukocytes from Parkinson’s Disease Patients: A Clinical Perspective on Biomarkers Identification
Objective: The aim of this work was to identify proteomic profiles associated with specific Parkinson’s disease (PD) clinical groups in leukocytes of patients from Rio…Evaluating IL6 and mitochondrial DNA levels as a potential biomarker in carriers of Parkin and PINK1 mutations
Objective: To discriminate affected PARK-Parkin and PARK-PINK1 mutation carriers from idiopathic Parkinson’s disease (PD) patients and healthy controls using serum IL-6 and mtDNA levels. Background:…Inflammatory Conditions in Parkinson’s Disease
Objective: The goal was to conduct a case-control study to assess associations between Parkinson disease (PD) and inflammatory conditions including allergies, asthma, eczema, atopic conditions,…Expression profiles from CD14+ monocytes in PD patients with GBA mutations
Objective: To study the pathogenic mechanisms associated with mutations of the GBAgenes in Parkinson’s disease (PD). Background: Mutation of GBA(encoding for glucocerebrosidase, GCase) is one of…
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