Serum Inflammatory Profile for the Discrimination of tremor severity in essential tremor
Objective: To establish the correlation between cytokines level in the serum of patients with ET and disease severity. Background: Essential tremor (ET) is the most…The interaction between iron metabolism and inflammation in Parkinson´s disease: an in vivo and post mortem study
Objective: To assess the relationship iron and inflammatory markers in an in vivo and post mortem study of Parkinson´s disease subjects. Background: Although neuroinflammation and…Blood Metagenomics Analyses of Brazilian Parkinson’s Disease Patients: A Clinical Substype Study
Objective: The goal of this study is to analyze the dormant microbiome present in blood of Parkinson’s disease (PD) patient and healthy controls samples by…7,8- Dihydroxyflavone prevents 3-NitropropionicAcid (3-NP)-induced Striatal Toxicity by Modulating the TrkB receptor and Microglial Activation Pathway
Objective: Hungtion’s disease (HD) is an autosomal governing neurodegenerative disorder caused by production of mutant hungtingtin(Htt) protein followed by death of the GABAergic neurons in…Functional Proteomic Analysis of Leukocytes from Parkinson’s Disease Patients: A Clinical Perspective on Biomarkers Identification
Objective: The aim of this work was to identify proteomic profiles associated with specific Parkinson’s disease (PD) clinical groups in leukocytes of patients from Rio…Association between peripheral inflammation and DATSCAN data of the striatal nuclei in different motor subtypes of Parkinson Disease
Objective: This work was designed to investigate peripheral inflammation in terms of Neutrophil-Lymphocyte ratio (NLR) concerning loss of dopaminergic uptake in caudate and putamen on…Role of microglia in the transmission of α-syn-containing exosomes
Objective: we investigated the role of microglia in the transmission of α-syn-containing exosomes and offer a new insight into the mechanism of PD pathogenesis. Background:…B lymphocytes may be protective in early Parkinson’s disease and in an animal model of dopaminergic cell death
Objective: To investigate B lymphocyte phenotype and function in human PD and in an animal model of disease. Background: The clinical course in Parkinson’s disease…Pharmacological modulation of lysosomal glucocerebrosidase activity in the Thy1-aSYN mouse model of Parkinson’s disease
Objective: To study the pharmacological modulation of glucocerebrosidase activity in the Thy1-aSYN mouse model of Parkinson's disease (PD). Background: PD is a complex neurodegenerative disorder…Nanoscale imaging reveals disorganization of the brain extracellular space in Lewy body-injected mice
Objective: To explore the brain extracellular space and its matrix at a nanometric scale in a context of α-synuclein-induced neurodegeneration. Background: The extracellular space (ECS)…
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