Alterations of NAD metabolism in symptomatic and asymptomatic carriers of pathogenic GCH1 variant
Objective: To investigate whether carriers of pathogenic GCH1 variant reveal lower NAD levels in the basal ganglia or the cerebellum compared to variant-free controls. Background:…Associations between Choroid Plexus and tau in Parkinson’s Disease
Objective: To investigate the associations between the choroid plexus (ChP) and protein indicators of Parkinson’s Disease (PD). Background: The ChP is the primary organ that…Predicting Freezing of Gait (FoG) in Parkinson’s Disease from Conventional T1-Weighted MRI
Objective: To predict freezing of gait in individuals with Parkinson's disease using T1-weighted MRI and machine learning techniques. Background: Freezing-of-gait (FoG) is a debilitating condition…One-year longitudinal decline in spatial location memory in Huntington’s disease
Objective: This study aimed to assess the capacity of the adapted version of the object-location memory task [1] to detect and monitor early Huntington’s Disease (HD) deficits.…Subtyping Parkinson’s Disease Mild Cognitive Impairment (PD-MCI) by Cholinergic Degeneration
Objective: This study aims to investigate whether PD-MCI patients exhibiting cholinergic degeneration, evidenced by reduced Ch4 grey matter density (GMD) on brain MRIs, constitute a…Frontal atrophy in progressive supranuclear palsy[PSP] -an universal feature along with midbrain atrophy?
Objective: To see if frontal atrophy is a frequent radiologic feature of PSP on MRI imaging . Background: Progressive supranuclear palsy[PSP] is a taupathy that…Comparison of Spontaneous Brain Activity in Distinguishing Parkinsonian Variant of Multiple System Atrophy from Parkinson’s Disease at Early Stage
Objective: The primary objective was to explore distinctions in the fractional amplitude of low-frequency fluctuation (fALFF) indicator among early-stage parkinsonian variant of multiple system atrophy…Early changes in the locus coeruleus in mild cognitive impairment with Lewy bodies
Objective: To evaluate NMS signal changes in the locus coeruleus (LC) in mild cognitive impairment with Lewy bodies (MCI-LB) as compared to healthy controls (HC)…MRgFUS thalamotomy for essential tremor: Lesion location and clinical outcomes
Objective: To examine the clinical outcomes and their relationship with patients’ baseline demographic and clinical features and lesion characteristics at 6-month follow-up in ET patients.…Clinical and Neuroimaging Biomarker Predictors of Autonomic Dysfunction in Parkinson’s Disease: A Study Using PPMI Data
Objective: To evaluate whether clinical and neuroimaging baseline markers predict the onset of significant dysautonomia over five years in individuals with idiopathic, de novo Parkinson's…
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