Cholinergic basal forebrain atrophy and cognitive decline in advanced Parkinson’s disease
Objective: To examine the relationship between cognitive decline and atrophy across cholinergic basal forebrain (BF) subregions in advanced Parkinson’s disease (PD). Background: Recent studies show…Noradrenergic terminal and locus coeruleus cell loss may be uncoupled in Parkinson’s disease – a PET and MRI multi-modal imaging study
Objective: To assess multimodal imaging of the noradrenergic system: magnetic resonance imaging (MRI) neuromelanin contrast of the locus coeruleus (LC) and noradrenalin transporter density with…Diffusion Magnetic Resonance Imaging with Neurite Orientation and Dispersion Imaging (NODDI) Detects Early Localized Cortex Disruption in Parkinson’s Disease
Objective: To use diffusion kurtosis MRI with NODDI to assess brain cortex microstructure in Parkinson’s patients and localize disease related changes. Background: Cortical atrophy has…Differential patterns of gray matter volume in responders and non-responders with Parkinson’s disease after deep brain stimulation
Objective: To identify the patterns of gray matter volume by voxel-based morphometry (VBM) in responders and non-responders with Parkinson’s disease (PD) after deep brain stimulation…Predictors of the progression of dementia with Lewy bodies
Objective: To define predictors of the progression of dementia with Lewy bodies (DLB). Background: Dementia with Lewy bodies is a progressive disabling neurodegenerative disease with…The dual cognitive syndrome in Parkinson’s disease: volumetric, morphological and tractometric features
Objective: To assess volumetric, morphological and tractometric features associated with the fronto-striatal and posterior cortical cognitive profiles in Parkinson’s Disease (PD) Background: The dual syndrome…Visualization of Nigrosome 1 at 3T MRI and 18F-DOPA PET for the diagnosis of Parkinson´s disease
Objective: To determine and compare the utility of Nigrosome 1 at 3T MRI and 18F-DOPA PET for the diagnosis of Parkinson´s disease. Background: Differential diagnosis…Regional free-water differentially associated with glial activation, neuroinflammation, and neurodegeneration in de novo Parkinson’s disease
Objective: Assess to what extent free-water(FW) as measured by diffusion-weighted MRI(dMRI) is a neuroimaging marker of glial activation, neuroinflammation, and neurodegeneration in de novo Parkinson’s disease(PD) patients from…Cerebellar structural covariance networks in young people with Tourette syndrome
Objective: To investigate discrete structural brain networks in children and adolescents with Tourette syndrome [TS] relative to a group of matched control participants. Background: TS…Defining time and anatomical specificity of basal ganglia white matter loss in premanifest Huntington’s disease
Objective: To identify when white matter connections first begin to degenerate in HD and which connections are most susceptible to early degeneration. Background: Huntington’s disease…
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