CJD presenting as unilateral upper limb dystonia- rare presentation of an uncommon disease.
Objective: This case illustrates the importance of neuroimaging in any patient who presents with focal dystonia and it may be an early manifestation of a…Evaluation of Perfusion, Iron Deposition, and Neuromelanin MRI Biomarkers Following Mesenchymal Stem Cell Treatment in a Phase 2 Parkinson’s Disease Trial
Objective: Evaluate the effects of allogeneic bone marrow-derived mesenchymal stem cell (allo-hMSC) infusions on neuroimaging biomarkers in patients with Parkinson’s disease (PD) using different MRI…Clinical and Neuroimaging Findings in ANO10-Related Cerebellar Ataxia: Evidence of Widespread Brain Atrophy
Objective: The aim of this study was to evaluate clinical manifestations and magnetic resonance imaging (MRI) changes in patients with ANO10 gene mutations. Background: Neurodegenerative…Increased Basal Ganglia And Default-Mode Network Connectivity And Altered Deep Gray Matter Volume In Functional Movement Disorders
Objective: This study aims to investigate alterations in brain functional connectivity (FC) and deep gray matter volume in patients with Functional Movement Disorders (FMD) compared…Decreased DTI-ALPS Indices and their Association with Clinical Features in Parkinson’s Disease
Objective: To investigate possible glymphatic dysfunction using diffusion tensor image along the perivascular space (DTI-ALPS) in patients with Parkinson’s disease and their relationship with clinical…Turning Points in Disease Progression: Detecting MRI Biomarker Transitions in SCA3 Using Longitudinal Data
Objective: This study aims to identify data-driven turning points in MRI biomarkers of SCA3 to characterize region-specific disease transitions and inform early intervention strategies. Background: SCA3…Impact 360 Study for Parkinson’s Disease – a controlled phase II feasibility and safety study of a combined exercise, diet and mindfulness intervention
Objective: The aim of this phase II controlled trial is to evaluate the safety, feasibility, and to explore the effects of a multimodal intervention in…Longitudinal MRI Study of Hippocampal Subfields Morphometry in Early Parkinson’s Disease
Objective: This prospective cohort study longitudinally investigated hippocampal subfield shape deformation and atrophy in early-stage Parkinson’s Disease (PD), using spherical harmonic-based shape analysis. Background: Hippocampal…Machine Learning Analysis of DTI-Derived Free Water Reveals Distinct Parkinson’s Disease Subtypes: A Two-Year Longitudinal Study
Objective: To identify distinct subtypes of Parkinson’s disease (PD) based on diffusion tensor imaging (DTI)-derived free water (FW) patterns in basal ganglia (BG) structures using…Brain Structural Impairment in Spinocerebellar Ataxia Type 6: Not Restricted to the Cerebellum
Objective: To characterize the structural brain signature in SCA6 patients. Background: Spinocerebellar ataxias (SCA) refer to a group of autosomal dominant ataxic disorders that result…
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