Analysis of Diagnostic Outcomes and Imaging Features in Patients with Ventriculomegaly and Gait Impairment
Objective: To describe the clinical features, diagnostic outcomes, and brain MRI imaging characteristics in patients with ventriculomegaly and gait impairment Background: Emerging evidence suggests that ventriculomegaly,…Huntington disease in a Patient with Extensive Psychiatric History
Objective: Huntington's Disease (HD) is an autosomal dominant neurodegenerative disorder resulting from an expansion of CAG trinucleotide repeats in the gene encoding the huntingtin protein.…Apolipoprotein E ɛ4-allele and Amygdala Atrophy in Parkinson’s Disease: A Preliminary Longitudinal Analysis from the ONDRI Cohort
Objective: To investigate the association of apolipoprotein E ɛ4-allele (APOE-ε4) with amygdala volumes longitudinally in Parkinson’s disease (PD). Background: APOE-ε4 is a genetic risk factor…Evaluation of swallow tail sign on 1.5 Tesla Magnetic Resonance Imaging in Parkinson´s disease patients in a tertiary hospital
Objective: To evaluate the swallow tail sign in 1.5 Tesla magnetic resonance imaging (MRI) scans of patients diagnosed with Parkinson's disease (PD). Background: Nigrosome-1 appears…Relationship Between Alpha-Synuclein Aggregation Profiles, Imaging Biomarkers, and Disease Severity in a Phase 2 Study of ATH434 in MSA
Objective: To investigate the relationships between α-synuclein aggregation profiles, imaging biomarkers, and UMSARS I scores in the ATH434-201 Phase 2 study. Background: Multiple system atrophy…Correlations of plasma glial fibrillary acidic protein levels with glymphatic system impairment in Huntington’s disease
Objective: To investigate whether plasma glial fibrillary acidic protein (GFAP) levels are related to glymphatic system function in Huntington's disease (HD). Background: Plasma GFAP levels has…Longitudinal Brain Morphometric Trajectories Across Parkinson Disease Clinical Subtypes
Objective: To investigate longitudinal brain morphometric trajectories across Parkinson disease (PD) clinical subtypes Background: We developed a PD multi-domain classification based on motor and non-motor…Clinical And Cerebellar Structural Alterations In Parkinson’s Disease Patients With Freezing Of Gait
Objective: To assess clinical and cerebellar volume differences in Parkinson’s disease (PD) patients with and without freezing of gait (PD-FoG and PD-NOFoG). Background: Cerebellum plays…Atrophy In Multiple System Atrophy Relates To Mitochondrial And Oligodendrocytic Processes
Objective: To investigate the gene expression and neurobiological underpinnings of brain atrophy in MSA using imaging transcriptomics and PET-based molecular annotation Background: The biological mechanisms…Widespread White Matter Changes in Manifest Huntington’s Disease
Objective: To characterize white matter changes in Huntington’s Disease (HD). Background: HD is a genetic neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. Diffusion Tensor…
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