MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Mitochondrial dysfunction"

  • 2023 International Congress

    To stimulate or not to stimulate? Bilateral subthalamic (STN) Deep Brain Stimulation (DBS) in cases of young-onset parkinsonism with mitochondrial dysfunction induced neurodegeneration.

    E. Efthymiou, B. Büchele, S. Mahendran, L. Stieglitz, C. Baumann, B. Balint (zurich, Switzerland)

    Objective: To describe two cases of young-onset parkinsonism (YOP; case 1 with mitochondrial membrane protein associated neurodegeneration (MPAN) due to a heterozygous mutation in C19orf12;…
  • 2023 International Congress

    Marked reduction of energy supply due to levodopa treatment in patients with Parkinson’s disease and healthy controls

    J. Prasuhn, T. Schiefen, T. Grüber, J. Hekel, J. Uter, J. Steinhardt, B. Wilms, N. Brüggemann (Lübeck, Germany)

    Objective: To investigate the influence of a standardized, placebo-controlled administration of levodopa on cerebral bioenergetics in patients with Parkinson’s disease (PwPD) and healthy controls (HCs).…
  • 2023 International Congress

    Use of insect model to study Parkinson’s disease pathophysiology by inducing GSH-depletion and behavioral deficits among larvae: Evidences of ameliorative properties of phytoconstituents

    G. Chandran, R. D'Silva, M. Muralidhara (MYSURU, India)

    Objective: The purpose of the study is to establish an all-around model for Parkinson's disease using Drosophila melanogaster, the fruit-fly in order to understand  behavioral…
  • 2023 International Congress

    The induction of mitochondrial damage by alpha synuclein In Parkinson’s disease.

    B. Adebisi (osogbo, Nigeria)

    Objective: Alpha synuclein aggregation have been indicted in the process of neuronal cell loss in Parkinson's disease; however, there have been several hypothesis to explain…
  • 2023 International Congress

    Movement disorders in children with neurometabolic and neurodegenerative disorders: A single-center prospective study

    A. Saini, S. Khanna, N. Sankhyan (Chandigarh, India)

    Objective: To analyze the prevalence, patterns and severity of movement disorders in children with genetically proven neurometabolic and neurodegenerative diseases. Background: Movement disorders are often…
  • 2023 International Congress

    Effects of a small molecule angiotensin IV analog on Huntington’s disease animal model

    R. Wells, A. Azzam, A. Hiller, M. Sardinia (Portland, USA)

    Objective: The present study was designed to test if N-hexanoic-Tyr-Ile-(6)-amino hexanoic amide (AngIV-6a), an angiotensin IV analog, could attenuate 3-nitropropionic acid-induced Huntington’s disease-like symptoms in…
  • 2023 International Congress

    Generalized dystonia and spasticity: The fault in the mitochondria

    A. Saini, S. Khanna (Chandigarh, India)

    Objective: To analyze the pattern of movement disorder in a child with mitochondrial respiratory chain disorder Background: Secondary movement disorders are often a clue to…
  • 2023 International Congress

    Impaired CaMKII/ERK activation in mouse mutant LRRK2 R1441G fibroblasts was associated with reduced mitochondrial calcium store and efflux in response to depolarization stress

    E. Chang, Y. Malki, Z. Choi, H. Liu, S. Zhang, S. Pang, M. Kung, D. Ramsden, S. Ho, P. Ho (Hong Kong, Hong Kong)

    Objective: To determine the molecular link of LRRK2R1441G mutation to impaired CaMKII/ERK signaling under mitochondrial depolarization stress using mutant mouse embryonic fibroblast (MEF) model of…
  • 2022 International Congress

    Effectiveness of Combined tDCS and tNIRS on Motor Performance in Parkinson’s Disease – A Single Case Study

    N. Choudhary (Jodhpur, India)

    Objective: The aim of the current study was to evaluate the synergistic effects of combining transcranial near infrared light stimulation (tNIRS) and transcranial direct current stimulation…
  • 2022 International Congress

    Functional validation of a mitochondria-specific polygenic risk score in patient-based models for stratification of idiopathic Parkinson’s disease

    G. Arena, Z. Landoulsi, A. Vitali, S. Delcambre, P. Antony, I. Boussaad, L. Pavelka, M. Sharma, E. Glaab, D. Grossmann, A. Grünewald, P. May, R. Krüger (Esch-sur-Alzette, Luxembourg)

    Objective: The overall objective of this project is to gain essential knowledge on the contribution of genetic variability in nuclear-encoded mitochondrial proteins to idiopathic Parkinson’s…
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