Distinct FDG PET Metabolic Signatures and Dopaminergic Loss Across Multiple System Atrophy Subtypes
Objective: To delineate subtype‑specific metabolic networks in Multiple system atrophy (MSA) using FDG‑PET, and to examine how these patterns relate to striatal dopamine transporter (DAT)…Prospective Comparison of Volumetric and Diffusion MRI Biomarkers for Multiple System Atrophy
Objective: We aimed to develop new imaging biomarkers allowing objective monitoring of early Multiple System Atrophy (MSA) progression, which could improve outcome definition for future…Quantitative Gait Evaluation in Multiple System Atrophy: Supervised versus Unsupervised Analysis
Objective: This study aims to compare gait parameters in real-world (RW) home settings with supervised clinical assessments on 6-minutes walking test (6MWT) in MSA patients…Clinical and Dopaminergic Characteristics of MSA-C Patients with Predominant Cerebellar Asymmetry
Objective: To identify multiple system atrophy–cerebellar type (MSA-C) patients with marked cerebellar asymmetry and compare their features with symmetrically affected patients. Background: While asymmetry is…Differences Between Clinical and Imaging Phenotypes in Phase 2 Study of ATH434 in Multiple System Atrophy
Objective: To assess differences between clinical and imaging phenotypes in Multiple System Atrophy (MSA) and evaluate the reliability of imaging biomarkers for subtype classification. Background:…Simple linear measurements of the putamen reliably differentiate MSA from other parkinsonian disorders on MRI.
Objective: This study evaluates the utility of simple linear measurements of the putamen to distinguish Multiple System Atrophy (MSA) from idiopathic Parkinson’s Disease (iPD) and…Novel Multiple System Atrophy Subtypes Identified Using Unsupervised Machine Learning Algorithms
Objective: To identify a novel disease subtype of multiple system atrophy (MSA) by applying machine learning algorithms to a large cohort of autopsy-confirmed MSA. Background:…Challenges in Diagnosing and Managing Multiple System Atrophy in Low-Resource Settings: Insights from Nepal
Objective: This study aims to explore the diagnostic and therapeutic challenges faced in the management of Multiple System Atrophy (MSA) in low-resource settings, focusing on…Intraepidermal Nerve Fiber Density at Baseline Associates with One-year Clinical Disease Progression in Multiple System Atrophy
Objective: In a longitudinal manner explore possible diagnostic and prognostic properties of determining intraepidermal nerve fiber density (IENFD), by means of skin punch biopsy, in…Unsupervised Learning Approach for Pathology-Based Subtyping and Staging Multiple System Atrophy
Objective: To develop a classification and staging system for multiple system atrophy (MSA) using data-driven disease progression modeling. Background: MSA exhibits varying degrees of degeneration…
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