Novel Multiple System Atrophy Subtypes Identified Using Unsupervised Machine Learning Algorithms
Objective: To identify a novel disease subtype of multiple system atrophy (MSA) by applying machine learning algorithms to a large cohort of autopsy-confirmed MSA. Background:…Natural history and epidemiological study of multiple system atrophy in Hokkaido: HoRC-MSA 2014-2025
Objective: To investigate epidemiological information of multiple system atrophy (MSA) patients in Hokkaido, Japan by using the registry data from the Hokkaido Rare-disease Consortium for…Intrathecal Administration of Human Oral Mucosa Neural Crest Stem Cells in Moderate/Advanced Multiple System Atrophy: Report on Ongoing Phase 1 Study
Objective: This first-in-human study aims to evaluate the safety of hOMNSC300 following intrathecal administration in patients with moderate to advanced MSA. Background: Stem cell therapy…Longitudinal FDG-PET Study of Metabolic Trajectories and Connectivity Alterations in Multiple System Atrophy
Objective: 本研究使用 FDG-PET 探索 MSA 中葡萄糖代谢和网络连接的纵向变化,以辅助早期诊断和监测疾病进展。 Background: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease with distinct metabolic patterns in its parkinsonian (MSA-P)…Neurogenic bladder and affective disorders in parkinsonism
Objective: To determine the relationship between psychoemotional and dysuria dysfunctions in patients with PD and MSA. Background: In the group of patients with extrapyramidal pathology…Balance confidence may not accurately assess fall risk in atypical parkinsonism
Objective: Objective: To examine if balance confidence, measured by the Activities-specific Balance Confidence (ABC) scale, reflects fall frequency in atypical parkinsonian syndromes (APS), namely multiple…Cardiac Autonomic Dysfunction in Patients with Multiple System Atrophy and Spinocerebellar Ataxia: A Comparative Study and Distinctive Machine Learning Model
Objective: To assess the differences of HRV parameters between MSA-C and SCA and their age-matched normal controls and also to use the supervised ML to…Multiple System Atrophy found during Evaluation of Palatal Myoclonus
Objective: To report a case of both Multiple System Atrophy (MSA) and Palatal Myoclonus (PM) suggesting that PM can be associated with neurodegeneration. Background: PM…Enhancing the differential diagnosis of atypical parkinsonian syndromes through a structured clinical acrostic
Objective: To develop a structured clinical acrostic for the differential diagnosis of atypical Parkinsonian syndromes. Background: The diagnosis of atypical parkinsonian syndromes (APS), including dementia…Pathology Meets Clinical Practice: Unveiling the Pathological Evidence of Clinical Signs in Multiple System Atrophy
Objective: This study aimed to evaluate the pathological evidence of the core and supportive clinical features of multiple system atrophy (MSA) based on The Movement…
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