Emotional, logistical and ethical aspects of voluntarily stopping eating and drinking in patients with movement disorders
Objective: We present two patients with atypical parkinsonism who chose to die by voluntarily stopping eating and drinking (VSED) to highlight the unique support and care needs associated…Attitudes on therapy-associated risks in individuals with multiple system atrophy and Parkinson’s disease and their views on aspects of clinical trials
Objective: To assess risk attitudes of patients suffering from multiple system atrophy (MSA) and Parkinson’s disease (PD) on future disease-modifying therapies as well as related…Non-invasive imaging markers of iron accumulation in Multiple System Atrophy
Objective: To define the localization and extent of iron accumulation in multiple system atrophy (MSA). Background: Elevated iron concentration in the basal ganglia has been…The effect of sleep positions on morning orthostatic hypotension in Multiple System Atrophy patients: A pilot study
Objective: To determine the effect of sleep position on morning OH in MSA patients Background: Dysautonomia is considered as one of the most distress symptom…Longitudinal 18F-PBR06 (TSPO) and Volumetric MR Imaging as Pharmacodynamic Endpoints for MSA – Ongoing Investigator Sponsored Trial of Verdiperstat
Objective: In multiple system atrophy (MSA) patients to: 1) evaluate 18F-PBR06 positron emission tomography (PET) for longitudinal assessment of 18-kilodalton-translocator protein (TSPO) binding; 2) assess…Body Weight-Supported Treadmill Training Improves Walking Function in Multiple System Atrophy: A Case Report
Objective: Multiple system atrophy (MSA) is a rapidly progressive synucleinopathy involving autonomic dysfunction and impaired mobility. MSA has been further sub-classified into two phenotypes: parkinsonian…Treatment of Neurogenic Orthostatic Hypotension (nOH) in Multiple System Atrophy (MSA) with a wearable Pneumatic Compression Garment utilising Soft Robotics
Objective: To use a novel Pneumatic Garment device for treatment of nOH in MSA. Background: nOH is present in 66-90% of patients with MSA and…Cardiac Safety of PBT434, an Inhibitor of Alpha-Synuclein Aggregation for the Treatment of Multiple System Atrophy (MSA)
Objective: Evaluate potential cardiac liability of PBT434 using concentration-response and outlier analyses of ECG and pharmacokinetic (PK) data from a Phase 1 study of PBT434…Physical Therapy Role with Differential Diagonosis and Treatment with Dizziness and Multiple System Atrophy: A Case Study
Objective: The purpose of this case study is to address the role of physical therapy (PT) in a case of complex dizziness, progressive symptoms, and…Effect of repetitive transcranial magnetic stimulation with intensive physical therapy in cerebellar ataxia: A pilot study
Objective: The present study investigated the efficacy and safety of combination treatment of repetitive transcranial magnetic stimulation (rTMS) and physical therapy (PT) in patients with…
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