Smell dysfunction correlates with severity of motor deficits in H&Y stage-I early onset Parkinson’s disease
Objective: The objective of this study is to test the hypotheses that: 1) olfactory dysfunction in early stage Parkinson’s disease (PD) is correlated with severity…Extending the spectrum of non-motor symptoms in pre-motor Huntington’s disease – a pilot study
Objective: The aim of this pilot study was to investigate change of olfactory functions in Huntington's disease. Background: Huntington's disease (HD) is a neurodegenerative disease…Defining LRRK2-PD subsets based on olfactory function in the PPMI
Objective: A major goal of the Parkinson Progression Marker Initiative (PPMI) is to identify clinical and biomarker defined disease subsets that may demonstrate differing disease…Serum uric acid as a putative biomarker in Prodromal Parkinson’s disease: Longitudinal data from the PPMI study.
Objective: Our present study assessed the role of serum uric acid as a putative biomarker in a prodromal PD cohort [REM Sleep Behavior disorder (RBD)…Comparisons Between Parkinson’s Disease Patients and At-Risk Individuals: Can Olfactory Deficits and Cognitive Measures Serve as Preclinical Markers?
Objective: To examine whether individuals at increased risk of developing Parkinson’s disease (PD) show specific cognitive impairments suggestive of progression towards PD. Background: Olfactory deficits…Serial DaT-SPECT imaging in asymptomatic carriers of LRRK2 G2019S mutation: 8-years follow-up
Objective: To characterize the 8-year progression of clinical and imaging biomarkers in a cohort of asymptomatic LRRK2 G2019S carriers and to assess its utility as predictors of…BASELINE OLFACTION TESTING IN PARKINSON’S DISEASE PATIENTS IS CORRELATED WITH LONG-TERM DOPAMINERGIC DENERVATION IN STRIATAL SUB-REGIONS: LONGITUDINAL DATA FROM THE PPMI STUDY.
Objective: The aim of the current study was to determine whether there are longitudinal differences in dopaminergic denervation of striatal sub-regions [signal reduction in 123I-FP-CIT…Relationship Between Hyposmia and Olfactory Network Connectivity in Patients With Parkinson’s Disease
Objective: To examine resting-state functional Magnetic Resonance Imaging in a group of Parkinson’s Disease patients, used to characterize changes in functional connectivity of the olfactory…Predictive value of UPSIT subsets in prodromal Parkinson disease
Objective: To assess the predictive value of previously published subsets of the University of Pennsylvania Smell Identification Test (UPSIT) odors for conversion to Parkinson disease…The role of dopamine mis-metabolism in preclinical Parkinson’s disease olfactory deficits
Objective: To gain an understanding of the underlying pathological mechanisms of Parkinson’s disease (PD)-related hyposmia using post-mortem human olfactory bulbs and an in vivo model…
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