A multiple-dose thorough QT study to evaluate the effect of ampreloxetine on cardiac repolarization in healthy subjects
Objective: To characterize the effect of therapeutic and supratherapeutic doses of ampreloxetine on cardiac repolarization in healthy subjects. Background: Ampreloxetine is a potent NE reuptake…Levodopa-induced orthostatic hypotension in a large cohort of patients with Parkinson’s disease undergoing an acute levodopa challenge test
Objective: We aimed to investigate the frequency and associated risk factors for Levodopa-induced orthostatic hypotension (OH) in a large cohort of PD patients underwent acute…Impact of orthostatic hypotension with sleep disturbance on cognition
Objective: To define features of cognitive decline in a group of patients with orthostatic hypotension combined with sleep disorders. Background: recent data suggest that orthostatic…An Analysis of Subgroups of Multiple System Atrophy Patients from Ampreloxetine Phase 3 Trials
Objective: To present results in the subset of patients with multiple system atrophy (MSA) and relevant MSA subgroups from two ampreloxetine phase 3 trials for…A randomized controlled trial comparing the efficacy and safety of pyridostigmine versus midodrine for the treatment of orthostatic hypotension in Parkinson’s disease patients
Objective: To assess the long-term efficacy and safety of pyridostigmine and midodrine in the treatment of OH in PD. Background: In Parkinson's disease (PD), orthostatic…Subclinical cognitive patterns of caudate-anchored connectivity in early Parkinson’s disease
Objective: This study is aimed at elucidating the changes of cognitive connectivity according to orthostatic stress in early Parkinson’s disease (PD). Background: 18F-Florbetaben tracer can…Autonomic dysfunction in p.A53T SNCA PD vs GBA PD and idiopathic PD : A study in a Greek population.
Objective: Τo assess whether autonomic dysfunction occurs in p.A53T SNCA mutation carriers manifesting Parkinson’s Disease (A53T-PD), using both subjective and objective measures and to compare…What is the appropriate sleep position for Parkinson’s disease patients with orthostatic hypotension in the morning?
Objective: To determine the effect of sleep positions on morning OH in PD patients Background: Orthostatic hypotension (OH) is considered one of the most disabling…Effect of lower limb vs. abdominal compression on mobility in orthostatic hypotension – a single-blinded, randomized, controlled, cross-over study in Parkinson’s disease
Objective: Orthostatic hypotension (OH) in Parkinson’s disease (PD) is frequent and associated with reduced quality of life and reduced activities of daily living. Abdominal binders…Caregiver burden in Parkinson’s Disease patients with Cardiovascular Dysautonomia
Objective: We sought to estimate the impact of cardiovascular autonomic neuropathy (cAN) on informal caregivers of patients with Parkinson’s disease (PD), defined as individuals providing regular…
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