A qualitative evaluation of the health-related quality of life impact on informal caregivers to patients with neurogenic orthostatic hypotension
Objective: This study aimed to explore the impact of caring for an individual with neurogenic orthostatic hypotension (nOH) through qualitative interviews with informal caregivers and…Leg muscle contractions compensate for declining cardiac baroreflex in PD Patients
Objective: To investigate if impairments in muscle contraction affects blood pressure (BP) regulation in PD. Background: Orthostatic hypotension (OH) contributes to unexpected falls in PD.…Locus coeruleus volume is reduced in Parkinson disease-related orthostatic hypotension.
Objective: To test whether structural pathology of the locus coeruleus (LC) is associated with orthostatic hypotension (OH) in Parkinson disease (PD). Background: OH is an…Prevalence of neurogenic orthostatic hypotension in the idiopathic Parkinson Progression Marker Initiative cohort.
Objective: To assess prevalence of neurogenic and peripheral orthostatic hypotension (nOH/pOH) in the PPMI (https://www.ppmi-info.org) idiopathic Parkinson disease (PD) cohort and to examine whether nOH,…Paradoxical cerebral hyperperfusion in Parkinson’s disease with orthostatic hypotension
Objective: This study manipulated the imaging modality to illustrate the physiology of cerebral flow with OH in PD (PD+OH). Background: Orthostatic hypotension (OH) may antedate…The effect of sleep positions on morning orthostatic hypotension in Multiple System Atrophy patients: A pilot study
Objective: To determine the effect of sleep position on morning OH in MSA patients Background: Dysautonomia is considered as one of the most distress symptom…Orthostatic hypotension in early onset Parkinson’s disease
Objective: To investigate Orthostatic hypotension (OH) feature in early onset Parkinson's disease (EOPD) , especially delayed OH and acute OH post drug. To explore OH…The Clinical Heterogeneity of Orthostatic Hypotension in PD Patients
Objective: The objects of the research were to investigate the clinical heterogeneity of orthostatic hypotension(OH) in PD Patients, to explore the possible risk factors for…Ampreloxetine (TD-9855), a long-acting, norepinephrine reuptake inhibitor (NRI) for the treatment of neurogenic orthostatic hypotension (nOH) in subjects with synucleinopathies: Phase 3 clinical program
Objective: To confirm: 1) clinical efficacy and safety of once-daily oral ampreloxetine in a 4-week double-blind (DB), placebo-controlled (PC) study (NCT03750552); 2) durability of efficacy…Treatment of Neurogenic Orthostatic Hypotension (nOH) in Multiple System Atrophy (MSA) with a wearable Pneumatic Compression Garment utilising Soft Robotics
Objective: To use a novel Pneumatic Garment device for treatment of nOH in MSA. Background: nOH is present in 66-90% of patients with MSA and…
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