Clinical Features of Multiple System Atrophy Across Diverse Populations: A Systematic Review of Subtypes and Diagnostic Frameworks
Objective: We aim 1) To describe the distribution of core clinical features of MSA, including age at onset, motor subtype, and cardinal symptoms, across global…Deep Learning-Enhanced Multimodal MRI for Real-World Differentiation of Parkinsonian Disorders
Objective: To develop and evaluate an integrated, deep learning (DL)-enhanced multimodal MRI classification model combining nigrosome-1 (N1), neuromelanin (NM), free-water DTI (FW-DTI) and morphometry (MORPHO)…Ante-Mortem Motor Speech Profiles in Postmortem Confirmed Atypical Parkinsonisms
Objective: Differences in motor speech profiles may aid in diagnosis of atypical parkinsonisms. This is a retrospective study that characterizes ante-mortem motor speech profiles in postmortem…[18F]-FDG-PET metabolic phenotyping in idiopathic normal pressure hydrocephalus: visual and voxel-wise evidence across neurodegenerative phenotypes
Objective: To characterise FDG-PET metabolic phenotypes in idiopathic normal pressure hydrocephalus (iNPH) using integrated visual and voxel-wise analyses. Background: iNPH is a potentially treatable cause…Parkinson’s Disease Duration at Total Knee Arthroplasty and 5-Year Vascular and Periprosthetic Outcomes: A Nationwide Matched Cohort Study
Objective: The objective of the study was to evaluate whether Parkinson's disease (PD) is associated with long-term risks of vascular events (cardiovascular and cerebrovascular) and…PDGFB Mutations may Induce Primary Brain Calcification via the Gain-of-Function Mechanism
Objective: This study aims to investigate the expression level of reported PDGFB mutations in human cerebral microvascular endothelial cells (hCMEC/D3), and further propose a potential…Knee Extensor Strength Is Associated with Torque Generation and Mobility in Parkinsonian Disorders
Objective: To examine associations among knee extensor strength (KES), torque generation during knee extension quantified by the area under the torque–time curve (AUC), and functional…Evaluating Generative AI Systems for Parkinsonism-related counseling: Bridging Accessibility Gaps through AI-Assisted Counseling
Objective: This study evaluated whether Generative Artificial Intelligence (GenAI) can provide accurate responses regarding Parkinsonism and serve as a supportive tool in palliative care. Background:…Movement Disorder Phenotypes in Neuronal Antibody–Mediated Autoimmune Encephalitis
Objective: To characterize movement disorder phenotypes in neuronal antibody–mediated autoimmune encephalitis (AE) and assess associations with specific antibody subtypes. Background: Neuronal antibody–mediated AE is a…Automated Differentiation for Early Parkinsonism Using Clinical Structural MRI: A Multicenter Study
Objective: To develop and validate a T1-weighted structural MRI–based machine learning model for differentiating Parkinsonism at early-to-mid stage and generalize the model to routine anisotropic…
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