Safety and efficacy of istradefylline, an adenosine A2A receptor antagonist, as a function of baseline dyskinesia (BL-dyskinesia) in Parkinson’s disease (PD): A pooled analysis of 4 studies
Objective: To evaluate the effect of BL-dyskinesia on the efficacy and safety of istradefylline in 4 randomized, placebo-controlled, double-blind, phase 2b/3 trials. Background: Istradefylline, a…Interpretation of health-related quality of life outcomes from the EARLYSTIM Study
Objective: To conduct a secondary analysis of the EARLYSTIM study1 to 1: Quantify the meaning of HRQoL outcomes and 2: Evaluate the changes of disease…Apomorphine Sublingual Film for On-Demand Treatment of “OFF” Episodes in Patients With Parkinson’s Disease: Effect on MDS-UPDRS Part III Subdomains
Objective: Evaluate effect of apomorphine sublingual film (APL-130277; APL) as an on-demand treatment of “OFF” episodes in patients with Parkinson’s disease (PD) on MDS-UPDRS Part…Can we customize tune for asymmetric tremor with differentiated Deep brain stimulation frequencies?
Objective: We aimed to display if differentiated frequency can improve the tremor in patients with STN-DBS. Background: Subthalamic deep brain stimulation (STN-DBS) is the best…The Indian Experience of Continuous Dopaminergic therapy with Apomorphine in Parkinson’s Disease
Objective: A clinical audit of apomorphine pumps – The Indian experience. Background: Continuous dopaminergic therapy remains crucial in the management of moderately advanced Parkinson’s disease…Neuroprotective and neuromodulatory properties of Olea purpurea leaf extract in MPTP intoxicated Parkinsonian rat model
Objective: This study aimed to isolate and characterize Olea purpurea leaf extract, and its neuroprotective effect in MPTP induced parkinsonian rat model. Background: Parkinson's disease (PD), also…FDG-PET degeneration patterns predict amyloid deposition in Corticobasal Syndrome
Objective: To investigate if an individual clinically-focused analysis of brain FDG-PET metabolic patterns and a comprehensive neurological evaluation could distinguish Corticobasal Syndrome (CBS) pathological variants…Intracranial Tuberculous Abcess with Acute Parkinsonism: Unusual Finding
Objective: A case report of central nervous system (CNS) tuberculosis infection with acute parkinsonism. Background: Neurotuberculosis is a recognized clinical entity which can present with…A sensor-based analysis of freezing of turning in bed: A new manifestation of nocturnal hypokinesia
Objective: To identify characteristics of freezing of turning in bed in PD patients using an axial inertial sensor (NIGHT-Recorder®) and synchronous video recording. Background: Freezing…What Matters Most to Individuals with Parkinson’s Disease: Results from Qualitative Interviews
Objective: To use interviews from individuals with Parkinson's disease (PD) to better understand the symptomology of the disease. Background: It is important to understand the…
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