LRRK2 p.G2019S and p.N2081D variants as modifiers of glucocerebrosidase activity
Objective: To examine whether the activity of the lysosomal enzyme glucocerebrosidase (GCase) is associated with LRRK2 variants. Background: Mutations in GBA (which encodes GCase) and…Loss of CHCHD2 and CHCHD10 disrupts mitochondrial cristae phenocopying patient mutations
Objective: Characterization of novel of a novel CHCHD2 (C2) and CHCHD10 (C10) knockout mouse model. Background: Dominant mutations in the mitochondrial paralogs CHCHD2 (C2) and…Sex differences on dynamic functional connectivity in Parkinson’s disease and healthy controls
Objective: The main objective was to evaluate the influence of sex in time-varying functional connectivity (FC) characteristics in Parkinson’s disease (PD) patients and healthy adults…Temporal properties of resting-state functional MRI are associated with ON/OFF levodopa MDS-UPDRS III scores in patients with Parkinson’s disease
Objective: To explore the relationship between temporal resting-state functional magnetic resonance imaging (fMRI) properties and ON/OFF Levodopa motor performance scores in patients with Parkinson's disease…Identifying neural signatures of Parkinson’s disease that predict decline in gait and postural control
Objective: To identify Parkinson’s disease [PD] specific patterns in the brain using a multi-modal neuroimaging design and use these to predict gait decline. Background: Gait…Visual Motion Perception and Metacognition in Parkinson’s disease
Objective: To investigate visual motion perception as a potential contributor to impaired visual self-motion perception in PD. To measured metacognitive ability and bias in PD…Impact of Chronotypes and melatonin levels on sleep disorders in patients with Parkinson’s disease
Objective: To investigate the sleep problems and circadian rhythm abnormalities in PD patients using sleep evaluation scale – Parkinsons disease sleep scale (PDSS) for mild…Higher adherence to MIND diet associated with later onset of Parkinson’s disease
Objective: This study evaluated the impact of MIND diet adherence on Parkinson’s disease (PD) onset and related symptoms. Background: PD is a common neurodegenerative disease…Sleep disturbances in Vascular Parkinsonism (VP) and Parkinson’s Disease (PD) patients in early stages
Objective: Compare sleep disturbances between VP and PD patients. Background: Sleep disorders in PD patients are well recognized, ranging from nocturnal symptoms such as insomnia,…A Parkinson’s disease (PD) case with underlying cerebral small vessel disease (CSVD)
Objective: Emphasis of CSVD in PD through clinical-pathological correlation study. Background: PD affects 1.7%, while CSVD affects about 45% [1], of the population aged over…
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