Amplification of α-synuclein aggregates in cerebrospinal fluid by rapid ultrasonication-based assay
Objective: To apply an ultrasonication-based misfolded protein amplification to the evaluation of α-synuclein aggregates in CSF, and to investigate their clinical significances in Parkinson’s disease…Evaluating the real-world effectiveness of carbidopa/levodopa enteral suspension (CLES) on patients with advanced Parkinson’s disease in USA: Interim-evidence from the PROviDE study
Objective: To evaluate the real-world effectiveness of carbidopa/levodopa enteral suspension (CLES) in patients with advanced Parkinson’s disease (PD) in real world at home setting in…Ataxin-2 gene in the Cuban population: Mutagenesis and epigenetic DNA methylation disease influencing phenotype
Objective: To characterize genetics and epigenetics factors contributing to the origin and accounting to the Cuban SCA2 phenotype variability. Background: CAG repeat expansions in ATXN2…Apathy : Clinical Correlates in Parkinson’s disease Psychosis
Objective: To determine the frequency and clinical correlates of apathy in Parkinson’s disease (PD) psychosis. Background: The underlying pathology of apathy in PD psychosis, itself…GBA p.Glu326Lys substitution increases the risk to develop Parkinson’s disease; is it enough to affect disease phenotype?
Objective: To evaluate the frequency of GBA p.Glu326Lys (E326K) carriers in a large cohort of Parkinson's disease patients of Ashkenazi Jewish origin (AJPD) and to…GBA and ATP13A mutation and PD: clinical phenotype, eye movements and pathogenic implications
Objective: To characterize a patient with GBAand ATP13A2gene mutations. Background: Mutations of GBA(Glucocerebrosidase) and ATP13A2(P5-ATPase) genes are risk factors for Parkinson’s disease (PD). Homozygous mutations…Cerebrotendinous Xanthomatosis presenting Parkinsonism with bilateral iron accumulation in the basal ganglia
Objective: Cerebrontendinous xanthomatosis(CTX) is a treatable, autosomal recessive, lipid storage disorder disease. Herein, we present a case of CTX. It aims to refresh and improve…Startle Reflex as a possible biomarker associated with REM sleep behavior disorders in the prodromal stage of Parkinson’s disease
Objective: 1. To test whether the alterations of REM sleep induced by lesions of the key areas involved in RBD pathogenesis are correlated to abnormalities…Pre-Dopa DBS: is early deep brain stimulation able to modify the natural course of Parkinson’s disease?
Objective: We review the state-of-the-art for deep brain stimulation (DBS) in Parkinson’s disease (PD) management, and present a case-series to evaluate the potential of DBS…Classification of Neurorehabilitation treatments: Preliminary results of a Multicentre Italian Study
Objective: To taxonomize the contents of neurorehabilitation programs and categorize goals and treatments provided to people with Parkinson Disease(PD) and Multiple Sclerosis(MS) to understand their…
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