A UK-wide Effort for Identification of Loci for Autosomal Dominant Parkinson’s Disease
Objective: (i) To describe the demographic, clinical and genetic features of a large cohort of familial autosomal dominant Parkinson’s disease (PD) patients in the UK.(ii)…The Inhibition of Mitochondrial NLRP3 Inflammasome Decreases Dopaminergic Cell Death in a 6-OHDA Mouse Model of Parkinson’s Disease.
Objective: To evaluate the possible neuroprotective effects of mitochondrial NLRP3 inflammasome inhibition in a 6-hydroxydopamine mouse model of Parkinson's Disease. Background: Overactivation of brain immune…Wilson’s Disease About A Complex Case
Objective: We report the case of a patient who experienced diagnostic wavering. Background: Wilson disease is a rare disease. Cases in Africa is even rarer.…Plasma MicroRNA Expression Profiling in patients with Multiple System Atrophy and Parkinson’s Disease
Objective: Our objective was to identify differentially expressed, circulating miRNAs in Multiple System Atrophy-Parkinsonian type (MSA-P) and Parkinson’s disease (PD) which could serve as diagnostic…Mild Behavioral Impairment in Lewy body disease: a potential marker of phenoconversion and disease severity
Objective: To explore the association between mild behavioral impairment (MBI) and disease severity in a predefined prospective cohort with Lewy body disease (LBD) spectrum Background:…Real-world use of biomarkers for Parkinsonism: Should I do this (pSyn) or DaT?
Objective: To examine the utility of commercially available skin phosphorylated alpha-synuclein deposition test (pSyn) in patients with clinically ambiguous parkinsonism and its concordance with dopamine…Parkinsonism in setting of hypoparathyroidism
Objective: There may be overlap between symptoms of hypoparathyroidism such as tremor and bradykinesia and Parkinsonism. Recognizing this possibility allows for appropriate clinical management. Background:…Association between Parkinsonism, Parkinson’s Disease and Cognitive Impairment and Incidence of Dementia in People with Parkinsonism and Parkinson’s Disease in Latin America: A 10/66 Dementia Research Group Study
Objective: The study aimed to determine the cross-sectional and prospective associations between parkinsonism and Parkinson's disease with cognitive impairment and dementia in a large multi-country…Spectrum of Movement Disorders in Kazakhstan: Five Years of Insights from Kazakhstan’s First Movement Disorder Center
Objective: To describe the spectrum, demographics, and trends of movement disorders patients seen at the first movement disorder (MD) center in Kazakhstan over five years.To…Pre-treatment with Methanolic Extract Mucuna pruriens Seeds Attenuates Serotonin Gene Depletion, Motor Dysfunction and Anxiogenic Responses in a Rat Model of Parkinsonism
Objective: Investigate neuroprotective and genoprotective effects of methanolic Mucuna pruriens (Mp) seed extract in a paraquat-induced Parkinsonism rat model. Background: Paraquat exposure has been linked…
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