Efficacy and safety of a L-dopa delivery and monitoring medical device
Objective: The objective of this study is to evaluate algorithms in a medical device for l-dopa delivery and monitoring. This wearable medical device will measure…Familial Parkinson’s disease in Ireland
Objective: To study the phenotype and subtypes of familial Parkinson's disease (PD) in Ireland, establish the genetic background in a cohort of Irish PD patients…SMPD1 mutations, acid-sphingomyelinase activity and α-synuclein accumulation in Parkinson’s disease
Objective: To study the effects of SMPD1 (sphingomyelin phosphodiesterase-1 gene) variants and acid-sphingomyelinase (ASMase) activity on Parkinson's disease (PD), and the effect of SMPD1 knockdown…Relationships of cognitive functions and psychiatric symptoms with motor phenotypes in patients with untreated early-stage Parkinson’s disease
Objective: It has been shown that the clinical types of Parkinson's disease (PD) based on motor symptoms include motor phenotypes of postural instability and gait…Drp1 inhibition amelioratesα-synuclein-mediated neurodegeneration in rats
Objective: To provide new insights on the relationships occurring between mitochondria physiology and α-synuclein (α-syn) accumulation in an animal model of progressive neurodegeneration. Background: In…Is the assessment of 5 meters of gait with body-worn-sensors enough to recognize Parkinsonian gait?
Objective: To classify step-by-step gait patterns of Parkinson's disease (PD) patients and older adults from the assessment of short episodes of gait with body-worn-sensors (BFS)…α-synuclein CSF levels correlate with urinary dysfunction in early de novo Parkinson’s disease patients
Objective: To explore the association between levels of α-synuclein burden and urinary dysfunction in early de novo (untreated) Parkinson's disease (PD) patients. Background: Urinary dysfunction…Sodium butyrate attenuates rotenone-induced neurodegeneration via enhancing autophagy and preventing α-synuclein aggregation
Objective: To investigate whether sodium butyrate (NaB) could enhance autophagy and thus exert a neuroprotective effect through the modulation of α-synuclein in animal models of…Lrrk2 alleles modify host response to microbial infections
Objective: The mechanisms by which allelic changes in LRRK2 modulate the susceptibility to Parkinson's disease, Crohn's disease and leprosy remain unknown. We hypothesized that leucine-rich…Analysis of LINGO1 and LINGO2 genes in essential tremor and Parkinson’s disease
Objective: We studied the involvement of LINGO1 and LINGO2 in Russian patients with ET and PD. Background: Genetics of ET is unclear. Three candidate loci…
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