Worse Sleep Quality Aggravates the Motor and Non-Motor Symptoms in Parkinson’s Disease
Objective: The current study aims to investigate the association of sleep characteristics with motor and non-motor dysfunctions of Parkinson’s disease (PD) in a single-center, observational,…Parkinsonian disorders may have different pain features.
Objective: The aim of this study was whether the pain is a unique feature of Parkinson's disease, which precedes motor symptoms, and its characteristics would…ASYMMETRIC EARLY-ONSET PARKINSONISM DUE TO PSEN1 MUTATION
Objective: To report a novel case of early-onset parkinsonism due to a presenilin 1 gene (PSEN1) mutation. Background: Mutations in PSEN1 gene are the most…Development of C-terminal α-Synuclein Vaccine for Treatment and Prevention of Parkinson’s Disease and Other Synucleinopathies
Objective: Prothena is developing active vaccine candidates targeting α-synuclein (α-syn) epitopes shown in clinical and/or preclinical studies to disrupt synuclein pathology. These vaccines, which target…Assessment of cognitive functions and gait in PD and ET patients with pharmacoresistant tremor treated with Gamma Knife thalamotomy.
Objective: The aim of our study was to assess the impact of unilateral Gamma Knife thalamotomy on gait and balance and well as psychological functioning…Alpha-synuclein fibril-based mouse model of REM sleep behavior disorder as a prodrome of synucleinopathy
Objective: To investigate whether in wild-type mice, inoculation of α-synuclein (aSyn) preformed fibrils (PFFs) into the sublaterodorsal tegmental nucleus (SLD), a core structure associated with…Safinamide as an adjunct to Levodopa Therapy in Asian and Caucasian Patients with Parkinson’s Disease and Motor Fluctuations: A post-hoc Analysis of the SETTLE study
Objective: This study evaluated the efficacy and safety outcomes of safinamide as a levodopa adjunct therapy in Asian and Caucasian patients with Parkinson’s disease. Background:…A secretory vesicle failure in Parkinson’s disease occurs in human platelets
Objective: Since platelets use similar, if not the same, mechanisms to accumulate serotonin (5-HT) as dopaminergic neurons to store DA in their VS; we wonder…Vascular Causes of Atypical Parkinsonism Versus Vascular Contribution Towards Atypical Parkinsonism
Objective: In this study, we have compared the clinical features of atypical parkinsonism with high vascular load to find the difference between isolated vascular pathology…CLINICAL AND GENEOLOGICAL FEATURES OF PARKINSON’S DISEASE
Objective: The initial purpose of the work is to study the clinical and genealogical features of Parkinson's disease. Background: Currently, clinical genetics has a number…
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