Limitations of conventional dopaminergic medication in advanced Parkinson’s disease: results from 127 patients treated with Levodopa Carbidopa Intestinal Gel
Objective: To evaluate the characteristics of the last conventional dopaminergic treatments in a large cohort of patients with advanced Parkinson’s Disease (APD) treated with Levodopa…MAPT mutation frontotemporal dementia with parkinsonism: when previous results can skew the diagnosis
Objective: Case report presentation. Background: In frontotemporal dementia with parkinsonism (FTDP), several mutations in MAPT gene have been identified, and numerous family cases were reported,…α-Synuclein in sympathetic nerve fibers distinguishes PRKN from LRRK2 and other genetic forms of Parkinson’s Disease
Objective: This cross-sectional observational study compared magnitudes of intra-neuronal deposition of α-synuclein in common and rare genetic forms of Parkinson’s disease. Background: Cytoplasmic inclusions of…Distinct cholinergic reactivity to dopamine is related with differed parkinsonian tremor responsiveness
Objective: We aimed at exploring the mechanisms of differed tremor responsiveness to dopamine through investigating the cholinergic and dopaminergic reactivity during dopamine administration in PD.…Clinical profile and treatment outcomes of inherited hypermanganesemia among 27 Indian children: A retrospective multi-centric study
Objective: To describe clinical, laboratory features and treatment outcomes among children with IH-Mn Background: Inherited hypermanganesemia (IH-Mn) is a recently described neurogenetic condition caused by mutations…A Computer-Vision Based Method for Quantifying Parkinsonian Gait
Objective: We proposed and evaluated a novel approach for estimating severity of gait impairment in Parkinson’s disease using a computer vision-based methodology. Background: Gait is…Carboplatin, Paclitaxel, and Nivolumab-induced Parkinsonism Responsive to Levodopa
Objective: To present the first reported case of reversible, levodopa sensitive, chemotherapy- induced parkinsonism due to the combination of carboplatin, paclitaxel, and nivolumab. Background: Many case reports describe antineoplastic agents causing reversible parkinsonism, most commonly, cyclophosphamide, cytosine arabinoside, and cyclosporine. To our knowledge, drug-induced parkinsonism related to combination therapy of paclitaxel, carboplatin, and nivolumab has never been…Patient and Care Partner Perspectives on a Community-Based Outpatient Palliative Care Intervention for Parkinson’s Disease and Related Disorders
Objective: To understand patient and care partner perspectives on a community-based outpatient palliative care intervention for patients with Parkinson’s disease and related disorders (PDRD). Background:…Impulse Control Disorders Following Bilateral Subthalamic Deep Brain Stimulation for Parkinson’s Disease: The INTREPID Randomized Controlled Trial
Objective: To assess frequency and outcomes of impulsivity in study participants receiving bilateral subthalamic deep brain stimulation (STN-DBS) for treatment of Parkinson’s Disease (PD) who…The Implications of Pyramidal Signs in Multiple System Atrophy
Objective: To determine pyramidal signs in multiple system atrophy (MSA) and the associations with other clinical characteristics. Background: The clinical manifestations of MSA are comprised…
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