Spontaneous smoking cessation in a parkinsonian patient treated with apomorphine pump
Objective: To describe the case of a parkinsonian patient treated by apomorphine pump who stopped smoking without difficulty despite being dependent to nicotine. To explore…Comparing the effects of rosemary and selegiline on behavioral symptoms of Parkinson’s animal model in mice
Objective: Parkinson is from common disorders of central nervous system and the second disease in neurodegenerative diseases which occurs in 1% of people over the…Characterization of novel alpha-synuclein aggregation model of Parkinson’s disease
Objective: To establish and characterize a robust alpha-synuclein (aSyn) aggregation pathology research model to allow efficient drug development platform for Parkinson's disease (PD). Background: PD…Decline in the midbrain-to-pons ratio over one year can support the differentiation between PSP and IPD
Objective: The midbrain-to-pons ratio (MTPR) is considered as an important diagnostic biomarker to differentiate between progressive supranuclear palsy (PSP) and idiopathic Parkinson’s disease (IPD). Here,…May Safinamide have a Role in Atypical Parkinsonism? A Retrospective Study in Clinical Practice
Objective: To evaluate efficacy and safety of safinamide in atypical parkinsonian syndromes. Background: Safinamide (50-100 mg) has proved efficacy as an add-on treatment to levodopa…Predictors of Falls with Injuries in People with Parkinson’s Disease
Objective: To identify predictors of falls with injuries in people with Parkinson’s disease (PD). Background: Falls are common in people with PD and can lead…Do improvements to primary symptoms from sensory training differ in Parkinson’s disease ON vs. OFF dopaminergic medications?
Objective: Investigate whether the effects of sensory training differ ON vs. OFF medication in Parkinson’s disease using the Unified Parkinson’s Disease Rating Scale (UPDRS-III). Background:…Loss‐of‐function mutations in NR4A2 cause dopa‐responsive dystonia-parkinsonism
Objective: To report two patients with early-onset dystonia-parkinsonism as a result of loss-of-function mutations in nuclear receptor subfamily 4 group A member 2 (NR4A2). Background:…When and how to stop subthalamic deep brain stimulation in late-stage Parkinson’s disease
Objective: We sought to investigate the percentage of “poor stimulation responders” among late-stage Parkinson's disease (LSPD) patients for elaborating an algorithm to decide whether and…Correlation of Lead Location with Clinical Outcomes in a Double-Blinded Randomized Controlled Trial Evaluating Subthalamic Deep Brain Stimulation in Parkinson’s Disease (INTREPID)
Objective: To assess the relationship between lead location in the subthalamic nucleus (STN) and deep brain stimulation (DBS) outcomes as reported in the INTREPID clinical…
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