Identifying neural biomarkers of motivated behavior in Parkinson’s disease using sensing-capable DBS devices
Objective: To investigate neural correlates of motivated, goal directed behavior within the basal ganglia. Background: Apathy is a common and debilitating complication of Parkinson’s disease…Longitudinal changes in brain networks associated with clinical symptoms in idiopathic rapid eye movement sleep behavior disorder
Objective: We aimed to assess changes in brain functional networks and accompanying symptoms over years in patients with idiopathic rapid eye movement sleep behavior disorder…The spectrum of GBA mutations in the Korean population with Parkinson’s disease
Objective: We investigated the mutation spectrum of glucocerebrosidase (GBA) gene in Korean patients with Parkinson’s disease (GBA-PD). Background: Mutations in the GBA gene represent important…Morphometric assessment of age-associated neuronal changes in the human locus coeruleus
Objective: To delineate the age-related changes in the neuronal size and neuromelanin (NM) intensity in autopsied tissues of human locus coeruleus (LC). Background: Many studies…Heart-rate variability as a new marker for freezing predisposition in Parkinson’s disease
Objective: We aim to investigate for the first time whether it is possible to detect a predisposition for upcoming Freezing of Gait (FoG) events from…Population-Scale Long-Read Sequencing to Catalog Structural Variants in Parkinson’s Disease
Objective: We aimed to generate a population scale long-read sequencing dataset to begin to catalog structural variants in Parkinson’s disease (PD) to identify potential new variants…Controlled-release zolpidem improves freezing of gait and levodopa-induced dyskinesias in a patient with Parkinson’s disease.
Objective: To report a patient with Parkinson’s disease with freezing of gait and levodopa-induced dyskinesias who improved with zolpidem. Background: A 57-year-old man developed Parkinson’s…Parkin Coregulates Glutathione Metabolism in Adult Brain to Contribute to Redox Homeostasis
Objective: We sought to determine whether the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis in vivo. Background: The mechanisms by which…Functional network correlates of APOE ε4 allele in Parkinson’s disease
Objective: To investigate the influence of APOE ε4 allele on metabolic network activity and functional connectivity in patients with Parkinson's disease (PD). Background: Disease progression…Automated parcellation of the cerebellum in patients with newly diagnosed Parkinson’s disease
Objective: Quantitatively evaluate the gross morphology of individual cerebellar lobules, determine whether cerebellar anatomical changes occur early in the disease and whether changes were related…
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