Multicenter study of efficacy and safety of subcutaneous foslevodopa/foscarbidopa treatment initiation or switch from LD/CD intestinal gel
Objective: To describe a series of patients under treatment with subcutaneous foslevodopa/foscarbidopa, either as initiation therapy or after switching from intestinal levodopa/carbidopa. Background: Treatment with…Studying digenic Parkinson’s disease in a stem cell model carrying mutant p.N409S in the GBA1 gene and the homozygous deletion of exon 3 PARK2
Objective: We aim to study the combined effect of the GBA1 p.N409S mutation and a complete loss of Parkin based on a patient-based stem cell…The role of LRRK2 in regulating microglial activity in Parkinson’s disease
Objective: To investigate the effects of pathogenic LRRK2 mutations on lysosomal function and phagocytic activity of microglia. Background: The LRRK2 G2019S mutation is one of…Declining Lymphocyte Count and Lymphocyte-to-Neutrophil Ratio Following Parkinson’s Disease Diagnosis.
Objective: To replicate previous findings in a diverse East London population, further characterising changes in FBC constituents and evaluating their temporal association with PD diagnosis.…STN-DBS Frequency Effects in Parkinson’s: An fMRI Study
Objective: The study aimed to investigate the impact of deep brain stimulation (DBS) at varying frequencies on brain activation patterns during a motor (force-tracking [FT])…Clinical and Brain Morphological Characteristics of Early LRRK2-associated Parkinson Disease
Objective: To investigate the impact of LRRK2 mutation in Parkinson disease (PD) and to explore the preclinical markers of LRRK2 mutation carriers who will develop…The Contribution of APOE4 Genotype on Structural MRI in Parkinson’s Disease: A Study from the PPMI Cohort
Objective: To assess the contribution of Apolipoprotein E4 (APOE4) in Parkinson’s Disease (PD)-related cognitive impairment by analyzing its impact on Gray Matter Volume (GMV). Background:…The alteration of GABA and glutamate in Parkinson’s disease is related to motor executive dysfunction: a 7T-MRS study
Objective: To explore the possible metabolic alterations of primary motor cortices (M1) of Parkinson’s disease (PD) patients and prodromal PD using 7T proton magnetic resonance…The Feasibility of ICA in Parkinson’s Disease fMRI
Objective: To report the feasibility of ICA on the BOLD signals of a Parkinson’s Disease patient. Background: ICA is a mathematical method to decompose multivariate…Weight Changes After Deep Brain Stimulation for Parkinson’s Disease in The Registry for the Advancement of DBS in Parkinson’s Disease (RAD-PD)
Objective: To determine if weight changes occur after Deep Brain Stimulation (DBS) Surgery for Parkinson’s disease (PD). Background: PD patients lose weight with disease progression…
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