State of happiness as outcome measure in sleep disorders in Parkinson’s disease
Objective: The objective of this study was to evaluate state of hapiness as outcome measure in sleep disorders in PD. Background: Outcome measures are very…Combining MDS-UPDRS Parts 1 and 2: using the patient’s voice
Objective: To test whether the patient-derived MDS-UPDRS Parts assessing non-motor (Part 1) and motor (Part 2) functional impact of PD can be summed to render…Cervical percutaneous interferential current stimulation improves cough reflex and oral residue in patients with Parkinson’s disease
Objective: Patients with Parkinson's disease (PD) encounter various swallowing disorders. This study aimed to assess the effects of cervical percutaneous interferential current stimulation on pharyngeal…Opicapone as First-Line Strategy for the Treatment of Wearing-off in Korean Patients with Parkinson’s Disease
Objective: This study aimed to explore the efficacy of opicapone (OPC) 50 mg versus an extra 100 mg levodopa (L-dopa) dose to treat early wearing-off…Long-Term Safety and Efficacy of Foscarbidopa/Foslevodopa in Patients with Advanced Parkinson’s Disease: Results From an Ongoing Phase 3 Open-Label Extension with Up to 1 Year Follow-Up
Objective: Evaluate long-term safety and efficacy of foslevodopa/foscarbidopa (LDp/CDp) among people with advanced Parkinson’s disease (aPD). Background: As aPD progresses, erratic gastric emptying and pulsatile…Effects of Mental Practice on FOG in People with Parkinson’s Disease: a Randomized Clinical Trial
Objective: To compare the effects of an experimental intervention (EI) based on NCI with a control intervention (CI) of equal volume and intensity, differing only…Istradefylline effects on L-Dopa resistant tremor in Parkinson’s disease
Objective: Quantifying Istradefylline(IST) effects in L-Dopa(LD) resistant tremor in Parkinson’s disease(PD) patients. Background: The adenosine A2A receptors control the indirect pathway. Adenosine A2A receptor activation decreases…Incobotulinumtoxin A to Treat Sialorrhea in Parkinson’s Disease: a Real-life Study: 5-year Interim Results
Objective: We evaluate the long-term efficacy and safety of incobotulinumtoxinA injections in advanced Parkinson’s disease (PD) patients suffering from sialorrhea (10 injection cycles (IC)). Background:…Assessment of Motor and Non-Motor Alterations Impacting Functionality in Parkinson’s Disease Patients
Objective: To investigate the impact of motor and non-motor changes on the functionality of individuals with Parkinson's disease Background: Parkinson's disease (PD) is the second…Dose-dependent alterations of lysosomal activity and alpha-synuclein level in peripheral blood monocyte-derived macrophages and SH-SY5Y neuroblastoma cell line by upon inhibition of mTOR kinase activity
Objective: To evaluate the perceptivity of mTOR kinase activity inhibition for Parkinson's disease therapy (PD). Background: The protein kinase mTOR is currently considered as a…
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