Development of therapeutic substances for the disassembly of α-synuclein aggregates as disease-modifying treatment of synucleinopathies
Objective: Development of high-affinity ligands to α-synuclein (α-syn) for a therapeutic approach aiming for the disassembly of α-syn aggregates as a disease-modifying treatment of synucleinopathies.…Novel RAB39B stop mutation in patient with typical Early-Onset Parkinson’s disease
Objective: N/A Background: RAB proteins are small guanosine triphosphatases (GTPases) that are ubiquitous and expressed in all cell types regulating vesicular transport and intracellular membrane…Screening and Treatment of Depression in Parkinson’s Disease Within Movement Disorders Centers
Objective: Implement depression screening using a validated instrument for people with Parkinson’s (PWP) as part of standard of care in the specialist movement disorders setting…Zonisamide in advanced Parkinson’s disease: a randomized placebo-controlled study in Egyptian population
Objective: To investigate safety and efficacy of ZNS on motor ,non motor symptons and quality of life in advanced PD in egyptian populatiin Background: Zonisamide…DNA Methylation is associated with gene expression changes in sporadic Parkinson Disease in the PPMI cohort.
Objective: To compare baseline whole blood DNA methylation in unmedicated sporadic Parkinson Disease (sPD) and healthy control (HC) participants from PPMI. To evaluate whole blood…Genetic diagnosis of parkinsonian phenotype of Machado Joseph Diseasep (SCA-3) presenting with dopa induced dyskinesia
Objective: We report a rare type IV parkinsonian phenotype of MJD having a rare genetic mutation. SCA type 3 (SCA3), also known as Machado-Joseph disease…Сlinical neurological features of diabetic and non-diabetic patients with Parkinson’s disease.
Objective: In the last decade, attention has been focused on the relationship between neurodegeneration and abnormal insulin signaling in the central nervous system, insulin in…Longitudinal recordings of subthalamic local field potentials show intra-subject consistency of beta-based physiomarkers in Parkinson’s Disease
Objective: To investigate long-term consistency of spectral data features extracted from local field potential (LFP) recordings of the subthalamic nucleus (STN) in Parkinson’s disease (PD)…Text entry as a digital outcome in Parkinson’s disease patients (TEXT-PD): results from two exploratory studies
Objective: To evaluate the feasibility and psychometric properties of text entry (TE) and touch metrics as digital outcomes for PD patients. Background: TE on smartphones…Evaluation of cases of psychosis from opicapone safety data
Objective: Investigate the likelihood of association of Opicapone (OPC) with psychotic symptoms (other than hallucinations). Background: Neuropsychiatric symptoms frequently occur in Parkinson’s Disease (PD) patients,…
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