Random-Order Crossover Trial Assessing the Safety, Feasibility and Exploratory Efficacy of Two Mediterranean-Ketogenic Nutritional Interventions in Parkinson’s Disease
Objective: Assess the feasibility, safety and exploratory efficacy of two Mediterranean-ketogenic dietary interventions in individuals with Parkinson’s disease (PD). Background: Both Mediterranean and ketogenic diets…A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of the NLRP3 Inhibitor Vent-02 in Patients with Mild to Moderate Parkinson’s Disease
Objective: To describe the innovative Phase 2 study design aimed to investigate vent-02 in the treatment of PD. Background: NLRP3 hyperactivation plays a critical role…Ferritin-related Brain Iron Deposition in Parkinson’s Disease Involves α-Synuclein Pathology
Objective: To investigate plasma neuron-derived ferritin-containing extracellular vesicles (NDFEVs) differences between Parkinson’s disease (PD) patients and controls, assess their association with brain iron deposition, and explore the…The neuroprotective effects of Echinacoside on α-synuclein fibril-induced Parkinson’s disease mice model
Objective: This study further investigates the ameliorative effects of ECH on neurobehavioral abnormalities and nigrostriatal dopaminergic system impairment in α-synuclein preformed fibrils (α-Syn PFFs)-induced PD…Gastrointestinal Dysfunction and Levodopa Therapeutic Response in Parkinson’s Disease: A Brazilian Cross-sectional Study
Objective: To investigate the relation between constipation and the onset time of levodopa therapeutic effect in Parkinson's disease (PD). Background: Levodopa therapeutic response depends on…COMT-Inhibitors Clinical Experience In Early Motor Fluctuations. Three Months Analysis Of REONPARK Study
Objective: The REONPARK study aims to evaluate COMT inhibitors (COMTi) effectiveness and tolerability in alleviating motor complications associated with L-dopa treatment in Parkinson’s disease (PD)…Combining Machine Learning and Linear Mixed Models to Estimate Medication Effect in People with Parkinson’s Disease
Objective: To estimate medication effect, as the score difference between MDS-UPDRS III in OFF and ON-state, using a minimal set of clinical features. Background: The…Fecal Microbiota Transplantation for Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To assess Fecal Microbiota Transplantation (FMT) efficacy in improving Parkinson’s disease (PD) symptoms. Background: Dysregulation of the microbiome–gut–brain axis is a key pathophysiological mechanism…Mapping aggregate monopolar sensing data of beta power local field potentials onto a common subthalamic nucleus in Parkinson’s disease patients
Objective: Compare local field potential (LFP) magnitude and anatomical location measured from a chronically implanted deep brain stimulation (DBS) lead within the subthalamic nucleus (STN)…Clinical Characteristics of Sporadic Parkinson’s Disease with Negative CSF Alpha-synuclein Seed Amplification Assay
Objective: Define clinical characteristics of individuals with sporadic Parkinson’s disease (sPD) enrolled in the Parkinson’s Progression Markers Initiative (PPMI) who have a negative CSF alpha-synuclein…
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