GDNF Gene Therapy for Parkinson’s Disease (PD): Preliminary Safety and Clinical Findings from a Phase Ib Study
Objective: Assess the safety and tolerability of intraputaminal AAV2-GDNF in mild to moderate PD Background: Glial cell line-derived neurotrophic factor (GDNF) is critical for dopaminergic…A longitudinal evaluation of the peripheral immune phenotype in a cohort of Parkinson’s disease patients
Objective: To evaluate the suitable modifications of immunological parameters in a through characterized population of Italian PD patientsTo evaluate the suitable modifications of immunological parameters…Short and long-term Impact of Covid-19 Pandemic on motor and non-motor symptoms in Leucine-rich repeat kinase2 (LRRK2) associated Parkinson’s disease
Objective: To determine short and long-term impact of COVID-19 on motor(MS) and non-motor(NMS) symptoms among Tunisian PD patients according to Leucine-rich repeat kinase2 (LRRK2)-carrying status.…Impact of COVID-19 in Parkinson disease: preliminary analysis from a survey performed in a Peruvian PD cohort.
Objective: To analyze the impact of COVID-19 in Parkinson cases and healthy controls from a Peruvian population. Background: The COVID-19 pandemic have a profound impact…In-home remote assessment of the MDS-UPDRS Part III: multi-cultural development and validation of a guide for patients and care partners
Objective: To develop and validate a culturally-sensitive guide for the remote administration of the Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) Part III.…IkT-148009 as a potential disease-modifying therapy in PD
Objective: Modeling Parkinson’s disease in mice suggests c-Abl activation is required for PD initiation and progression, and therefore inhibition of c-Abl could be a strategy…Evaluation of Genetic influence of APOE on Clinical and motor functions among Idiopathic Parkinson’s Disease Patients; A comparative study
Objective: We studied the effect of APOE ε4 carriers and non-carriers on clinical and motor functions in patients with IPD Background: The significance of APOE…Validation of Direct/Indirect targets with intra-operative clinical assessment in the Indian population & comparison with image guided and MER based targeting for Subthalamic Nucleus(STN) based Deep Brain Stimulation(DBS) in Parkinson’s disease(PD)
Objective: This study attempts to validate the relationship between Direct-D, indirect-ID coordinates for STN in Indian subjects. Also, this study tries to compare the D,…Cross-cultural validation of the Cebuano version of a screening questionnaire for Parkinson’s Disease
Objective: To determine the validity of the Cebuano version of a PD screening questionnaire Background: In the Philippines, actual prevalence of Parkinson’s Disease (PD) is…COMBINED CSF α-SYN RT-QuIC, CSF NFL AND MIDBRAIN-PONS PLANIMETRY IN DEGENERATIVE PARKINSONISMS: FROM BEDSIDE TO BENCH, AND BACK AGAIN
Objective: (1) to assess the combined diagnostic ability of CSF NFL, CSF RT-QuIC α-SYN and midbrain/pons MRI measures in degenerative parkinsonisms; (2) to interpret results…
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