Metabolic Regulators of Mitochondrial DNA Release in Cellular Models of PRKN-linked Parkinson’s Disease
Objective: Explore metabolic modulation as a disease-modifying target for inflammation in PRKN-PD Background: The release of mitochondrial DNA (mtDNA) is a well-documented phenotype in PRKN-linked…Single cell transcriptomics of peripheral blood mononuclear cells and associations with clinical outcomes in Parkinson’s disease
Objective: To assess transcriptomics signatures for monocytes and T-cells in different stages of Parkinson’s disease (PD) compared to controls and possible correlations with clinical outcomes.…Motor and Non-Motor Outcomes of Bemdaneprocel in People With Parkinson’s Disease: Results up to 24 Months From a Phase 1 Study
Objective: To describe the effects of bemdaneprocel on motor and non-motor outcomes in participants with Parkinson’s disease (PD) up to 24 months post transplantation (12…Quantification of Neuroinflammation and White Matter Injury in Parkinson Disease Using Diffusion Basis Spectrum Imaging
Objective: To investigate differences in white matter (WM) using Diffusion Basis Spectrum Imaging (DBSI) between participants with Parkinson’s disease (PD) and controls and to examine…Cerebrovascular Reactivity and Glymphatic Clearance in Parkinson’s disease
Objective: To evaluate whether altered cerebrovascular reactivity contributes to reduced glymphatic clearance in Parkinson’s disease (PD). Background: Cerebrovascular activity is a major factor driving cerebrospinal…The 2-Minute Walking Test Predicts Aerobic Fitness, Motor Function, and Brain Health in Parkinson’s Disease
Objective: To determine the association of performance on the 2-Minute Walking Test (2MWT) with aerobic fitness, motor and cognitive function, and brain health in mild…Transcranial Sonography of the Substantia Nigra and Vagus Nerve Ultrasonography as Complementary Diagnosis for Parkinson’s Disease.
Objective: We aim to investigate the relationship between sonographic abnormalities of the substantia nigra, vagus nerve cross-sectional area and clinical features of PD in different…Safety and effectiveness of staged bilateral MR-guided focused ultrasound pallidothalamic tractotomy for motor complications of Parkinson’s disease: study protocol
Objective: To describe the protocol of a study evaluating the safety and effectiveness of magnetic resonance-guided focused ultrasound (MRgFUS) pallidothalamic tractotomy (PTT) as a staged…Subthalamic Local Field Potential Monitoring in Parkinson’s Disease during Epidural Electric Spinal Cord Stimulation
Objective: Investigate STN local field potential (LFP) changes in a patient with PD during spinal cord stimulation (SCS). Background: SCS is explored as a possible…Focused ultrasound subthalamotomy in early Parkinson´s disease: three-year prospective follow-up
Objective: To assess the safety and efficacy of focused ultrasound subthalamotomy (FUS-STN) for Parkinson´s disease (PD) in patients who received the procedure within the first…
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