GBA1 deficiency promotes the spread of Lewy pathology
Objective: To elucidate how GBA1 deficiency promotes the spread of Lewy pathology from cell to cell. Background: Mutations in the gene glucosidase, beta acid 1 (GBA1) not…Longitudinal Effects of Initial Deep Brain Stimulation Settings on Force-Tracking Brain Activation and Motor Performance in Parkinson’s Disease
Objective: To evaluate changes in force-tracking (FT) fMRI activation patterns and motor performance over time using initial deep brain stimulation (DBS) settings optimized after three…A novel potential imaging biomarker for Parkinson’s disease: Optical Coherence Tomography.
Objective: This observational cross-sectional study aims to explore the thickness of retinal layers in patients within the PD continuum, patients with isolated REM Sleep Behavior…Assessing Genome-wide Genetic Risk for Parkinson’s Disease Age at Onset in European Sub-Populations: from the Global Parkinson’s Genetics Program
Objective: To identify the genetic determinants of Parkinson’s disease (PD) age at onset (AAO) within and across genetically determined European ancestries (European, Ashkenazi Jewish, Finnish,…Distribution of Genomic Ancestries and Genetic Variation Among Individuals Enrolled in the PD GENEration Study
Objective: To assess the distribution of genomic ancestries and rates of positive genetic findings in individuals enrolled in a large-scale return of results study for…Smoking and Genetic Interactions in Parkinson’s Disease
Objective: To investigate the interaction between smoking and Asian-specific LRRK2 variants (G2385R and R1628P) in Parkinson’s disease (PD) risk, examining whether smoking modifies the genetic…Genetic variants detection and prevalence in Hawaii’s diverse PD population
Objective: To overcome access barriers to genetic testing and address the paucity of knowledge regarding genetic causes of PD among Hawaii’s racial and ethnic groups.…Unveiling Parkinson’s Disease Variants in the Chinese Population: The CPD10KGP Study
Objective: In response to these limitations, we are proposing the China Parkinson’s Disease 10,000 Genomes Project (CPD10KGP), which aims to delineate the genetic architecture of…The role of imaging in deep brain stimulation programming: a preliminary comparative study of image-guided vs. neuroimaging-guided automated approaches in Parkinson’s disease
Objective: To evaluate the imaging correlation between image-guided and neuroimaging-guided automated of bilateral STN stimulation in patients with PD. Background: Subthalamic deep brain stimulation (STN-DBS)…Levodopa and DBS Produce Discordant Effects on Parkinsonian Features
Objective: To compare the effect of levodopa vs deep brain stimulation on specific motor features of advanced Parkinson disease. Background: Levodopa (LD) is the gold…
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