Positive Relationship Between Improvement in Sleep and Quality of Life During Foslevodopa/Foscarbidopa Continuous Subcutaneous Infusion
Objective: To investigate the relationship between improvements in sleep disturbances and quality of life (QoL) in adults with advanced Parkinson’s disease (aPD) treated with a…Unraveling the Variability in Amantadine Response for Levodopa-Induced Dyskinesias: The Impact of Clinical and Genetic Factors
Objective: To identify demographic, clinical, and genetic factors associated with the outcomes of amantadine treatment in dyskinetic Parkinson’s disease (PD) patients. Background: While recent advancements…Treatment Stability Across Different ADD-ON Therapies in Fluctuating Parkinson’s Disease
Objective: This study investigates the efficacy and tolerability of selegiline (SL), rasagiline (RS), safinamide (SF), and opicapone (OP) in fluctuating PD patients, focusing on treatment…Phosphorylated High Mobility Group Box Protein 2 (HMGB2) as a Potential Biomarker for Parkinson’s Disease
Objective: We recently showed that HMGB2 is secreted during ferroptosis and as ferroptosis is involved in the etiology of PD, we have examined the possibility…Alpha-Synuclein Amplification Assays Utilizing Real-Time Quaking-Induced Conversion (RT-QuIC) from Non-Invasive Saliva as a Novel Diagnostic Tool for Patients with Parkinson’s Disease
Objective: The main objective is to evaluate the sensitivity of aSyn-RT-QuIC in diagnosing Parkinson's Disease (PD) from non-invasive saliva. The results will be corroborated in…Dried Plasma Spot Cards for Measurement of Neurofilament Light Chain
Objective: Evaluate measurement of neurofilament light chain (NfL) in dried plasma spot cards, and to compare these to measurements using more invasive and in person…Cognitive and Motor Wobbling in Isolated RBD: A Multicentric Study by the International RBD Study Group (IRBDSG)
Objective: To define and characterize clinically fluctuating transition phases from isolated RBD (iRBD) to overt alpha-synucleinopathy. Background: Patients with iRBD often develop motor and non-motor…Novel Usage of Alpha Synuclein as a Biomarker for Screening Parkinson’s disease at Komfo Anokye Teaching Hospital in Ghana
Objective: This study aimed to assess the use of alpha-synuclein as a biomarker for PD screening and investigate its correlation with disease severity. Background: The…Neural Signatures of Hallucination Emergence in Dementia with Lewy Bodies
Objective: REM sleep behavior disorder (RBD) is a prodromal state for alpha-synucleinopathy. Here, we present a behavioral marker for hallucination propensity that distinguishes Dementia with…Comparative Analysis of MoCA Scores Between Latin American Latinos and White Patients with Parkinson’s Disease
Objective: The study objectives were to 1) characterize scores on the Montreal Cognitive Assessment (MoCA) in patients with Parkinson’s disease (PD) from Latin America, 2)…
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