Effects of GBA mutations in patients with Parkinson’s disease and Levodopa-carbidopa intestinal gel: a nation-wide longitudinal multicentre ‘real-world’ study.
Objective: To investigate the safety and efficacy of LCIG in PD, focusing on the effects of GBA status. Background: Parkinson's disease carriers of GBA mutations/variants…Case Report Increasing ‘On-time’ Using Mucuna pruriens Concomitantly with Traditional Levodopa/carbidopa Management
Objective: Case study to see if concomitant use of the botanical Mucuna pruriens with traditional levodopa/carbidopa management could improve patient ‘off-time.’ Background: Mucuna pruriens is a pantropical legume…LRRK2 G2019S mutant damages mitochondrial transfer by a Drp1-STX17 depend pathway in Parkinson’s disease
Objective: We focus on the novel endogenous neural repair function that comes from the mitochondrial transfer, and we aim to elucidate the molecular mechanism by…Gut Microbiota May Alter Glucose Metabolism in Patients with Parkinson’s Disease
Objective: To compare the gut microbiota in patients with Parkinson’s disease (PD) and healthy controls and predict the functional pathways associated with these differences. Background:…Hemiparkinsonism Induction with 6-OHDA in Primates Does Not Induce SN Hyperechogenicity.
Objective: We aimed to investigate the changes in SN echogenicity in primate models of hemiparkinsonism induced by 6-OHDA. Background: Hyperechogenicity in the midbrain demonstrated by…Cortical morphometry and subcortical volumetry in motor subtypes of Parkinson’s disease
Objective: This study aims to evaluate the presence of differences in cortical morphometry and subcortical volumetry in tremor dominant Parkinson’s disease (TDPD) and postural instability…Neurovascular Involvement in Parkinson’s Disease Cognitive Impairment: A 4D Flow Study
Objective: To investigate the cerebrovascular contribution to cognitive decline in Parkinson’s disease (PD). Background: Cognitive impairment is a major non-motor feature of PD. Accruing evidence…Refining and Understanding Causal Relationships between Brain Imaging-Derived Phenotypes and Parkinson’s Disease: a Bidirectional Mendelian Randomization Study and Clinical Validation
Objective: Utilizing bidirectional two-sample Mendelian randomization, we explored the causal associations between imaging-derived phenotypes (IDPs) and Parkinson's Disease (PD), along with its manifestations. Background: Observational…Altered Dynamic Functional Connectivity in Parkinson’s Disease Individuals with Visual Hallucinations and Dysfunction
Objective: Parkinson’s disease (PD) is frequently accompanied by visual disturbances (VD) and visual hallucinations (VH). This study aimed to analyze the alterations of Dynamic Functional…Long-term effects of Deep Brain Stimulation on gait and postural control in Parkinson’s disease
Objective: To investigate the effects of deep brain stimulation (DBS) on gait and postural control in patients with Parkinson's disease (PD) two years after surgery.…
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