Deferiprone improves striatal dopamine by reducing neuroinflammation and oxidative stress in MPTP-induced mice model of Parkinson’s disease
Objective: This study aimed to investigate the effect of deferiprone on the striatal DA, oxidative stress and neuroinflammation markers as well as motor deficits in…Rescuing alpha-synuclein toxicity through neuron-specific enhancement of autophagy
Objective: In the present study, we aim to counteract regulatory and transcriptional modifiers of autophagy to enhance neuroprotective proteostasis and rescue alpha-synuclein (asyn) toxicity in…Mathematical and Computational Modeling Prototype to Understand the Evolution of Parkinson’s disease using Four Differential Equations
Objective: Apply four differential equations to generate projections considering the effect of dopamine on Parkinson’s disease progression, leading to the development of an initial prototype…Comparison of MIBG Uptake in the Major Salivary Glands Between Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease
Objective: This study aimed to evaluate 123I-metaiodobenzylguanidine (MIBG) uptake in the major salivary glands (MSG) in patients with rapid eye movement sleep behavior disorder (RBD)…Multiparametric Prediction of Mild Cognitive Impairment in Parkinson’s Disease Using a Combination of Structural and Functional MRI Measures
Objective: To investigate whether the multiparametric combination of structural and functional (fMRI) neuroimaging parameters improves the prediction of mild cognitive impairment (MCI) in Parkinson's disease…Impact of Aquaporin-4 polymorphisms on Glymphatic Function and Motor Symptoms in Parkinson’s Disease
Objective: This study aims to investigate whether single-nucleotide polymorphisms (SNPs) of the Aquaporin-4(AQP4) gene were related to abnormal protein accumulation (α-synuclein), glymphatic dysfunction (DTI-ALPS), and…Whole Genome Sequencing of an Early-onset Malaysian Parkinson’s Disease Cohort
Objective: To investigate the genetic causes of Malaysian early-onset Parkinson’s disease (EOPD) patients with whole genome sequencing (WGS). Background: EOPD (age of diagnosis ≤50 years)…Familial parkinson disease A comparative study between LRRK2 and PINK 1 mutations
Objective: Describe the clinical phenotypes of monogenic forms of PD linked to LRRK2 and PINK1 mutations with a view to a comparative study between the…Retinal Structural Changes in Parkinson’s Disease: insight into GBA1-Related PD and non-mutated PD
Objective: The study aims to explore differences in retinal thickness between GBA1-related Parkinson Disease (GBA1-PD) and non-mutated PD (NM-PD) and to analyze correlations between clinical…Association Analysis Between Genotypes and Disease Progression in Parkinson’s Disease
Objective: To investigate the relationship between genetic subtypes and disease progression in Early-Onset Parkinson’s Disease (EOPD) . Background: Genetic factors play a critical role in…
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