A Long-Living Human Tissue Engineered Nigrostriatal Pathway as a Testbed to Study Parkinson’s Disease
Objective: To create a three dimensional (3D) long-living model of human tissue-engineered nigrostriatal pathway (TE-NSP) comprised of discrete somatic and axonal compartments recapitulating the native…Metabolic Imaging Correlates of Apathy in Parkinson’s Disease.
Objective: To investigate apathy-associated metabolic changes in Parkinson’s disease. Background: Apathy is a behavioral syndrome manifested as a decrease in goal-directed behaviors. It has been…Spatial Multi-Omics Identifies Early Synaptic Pruning and Context-Specific Dopaminergic Vulnerability in Synucleinopathies
Objective: To investigate the significance of Lewy body pathology (LBP) in relation to midbrain molecular and cellular changes associated with Parkinson's disease (PD). Background: The…Striatal dopamine- and basal forebrain cholinergic-dependent brain metabolism and cognition in Parkinson’s disease
Objective: To explore the interrelation of striatal dopamine, cholinergic basal forebrain volume, brain metabolism, and cognition in PD. Background: Parkinson’s disease (PD) involves multiple neurotransmitter…STN Iron Content Correlates with DBS Efficacy in Parkinson’s Patients: a Preliminary Study
Objective: Evaluate the relationship between baseline iron levels in the subthalamic nucleus (STN) and their impact on motor function and dopaminergic medication needs after deep…Sex-specific genetic architecture of autosomal risk for Parkinson’s Disease: from the Global Parkinson’s Genetics Program
Objective: To investigate potential differences in autosomal risk factors between males and females with Parkinson’s Disease (PD). This analysis was performed within and across genetically…Returning Secondary Health Findings in the PD GENEration study
Objective: To provide secondary health findings (SHF) results to participants enrolled in the PD GENEration study via CLIA genetic testing using whole genome sequencing (WGS)…Identifying Differential DNA Methylation Pathways in Parkinson’s Disease and REM Sleep Behavior Disorder
Objective: To investigate differential methylation patterns of cell-free DNA (cfDNA) between Parkinson’s Disease (PD), REM Sleep Behavior Disorder (RBD), and Healthy Control (HC) groups. Background:…Studying the Influence of Genetic Variations on Functional Performance in Parkinson’s Disease
Objective: To evaluate whether individuals with one of the seven most common genetic variants associated with Parkinson’s Disease (PD) exhibit differences in physical function performance…Revealing Novel Genetic Contributors to Parkinson’s Disease in a Chinese Cohort: An Elaborate Examination within the CPD10KGP
Objective: This study employs next-generation sequencing (NGS) and long-read sequencing data (LRS) in Chinese AR-PD families to uncover novel genes, enhancing our genetic comprehension of PD. Background:…
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