RNA binding protein mediated regulation of striatal transcriptome in Parkinson’s disease.
Objective: To investigate the role of RNA binding protein Elavl in Parkinson’s disease related adaptive changes in the striatal transcriptome. Background: Elav-like (Elavl or Hu)…Synchronization Study of Regional Local Field Potential in Rat with Dopamine Receptor Stimulation
Objective: The aim of this study attempts to explore the non-linear interaction with cross-frequency coupling in rats during the stimulation of dopamine receptors. Background: Investigating…Emulating the natural timing of dopamine receptor activation in Parkinson’s Disease
Objective: To emulate physiological dopamine receptor activation, in order to restore temporal patterns of dopamine-like signalling and normalise function in the striatum in Parkinson's disease.…A Case of Parkinsonism due to the Hypoxic-Ischemic Lesions of the Striatum
Objective: To present a case of parkinsonism due to the hypoxic-ischemic lesions of the striatum. Background: Parkinsonism due to the basal ganglia lesions caused by…Motor and cognitive deficits in a mouse model of tauopathy with tau isoforms imbalance: Potential therapeutic strategies
Objective: This work investigates motor phenotypes and neurochemical changes in a mouse model of tauopathy linked to tau mis-splicing. We sought to validate a potential…Closed loop spinal cord stimulation restores locomotion and desynchronizes corticostriatal beta oscillations
Objective: To test if closed loop Spinal Cord Stimulation (SCS) could be used to restore locomotion in a 6-hydroxydopamine (6-OHDA ) rodent model of Parkinson's…Longitudinal decline in white matter integrity in Parkinson’s disease: An analysis of Parkinson Progression Markers Initiative diffusion tensor imaging data
Objective: To determine the relative changes in white matter integrity as measured by diffusion tensor imaging (DTI) magnetic resonance imaging (MRI) in PD patients relative…Contribution of individual motor signs to striatal dopamine deficiency in parkinsonism
Objective: The primary aim of the study was to investigate if any individual motor sign could be used clinically to predict striatal dopamine deficiency. Secondary…A longitudinal PET study to assess progression of laterality in Parkinson’s disease
Objective: This study aims to identify in Parkinson’s disease (PD) whether striatal dopamine transporter (DAT) losses occur at a similar rate in both sides of…Alteration to Basal Ganglia Morphology in Freezing of Gait in Parkinson’s Disease
Objective: To characterize the subcortical grey matter adaptations related to Freezing of Gait in Parkinson’s Disease (PD). Background: Owing to its connections with motor, cognitive…
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