Tau Neuropathology Associates with In Vivo Patterns of Neurodegeneration in Lewy Body Disorders
Objective: Investigate the impact of Alzheimer’s disease (AD) co-pathology on an in vivo structural measure of neurodegeneration in Lewy Body disorders (LBD: Parkinson’s Disease and…Identification and characterization of anti-prionic compounds that disassemble Tau prions as a novel therapeutic approach for tauopathies
Objective: Stabilization of monomeric Tau protein by transient and high-affinity binding ligands is a novel and highly innovative anti-prionic treatment strategy for tauopathies. Background: Tauopathies…Mixed pathologies in pancreatic beta-cells from subjects with neurodegenerative diseases and their interaction with prion protein
Objective: We studied whether, as in the brain, pancreatic -cells of subjects with neurodegenerative diseases also present co-occurrence of other misfolded proteins. Furthermore, we also assessed…Clinical features and natural course of corticobasal degeneration and progressive supranuclear palsy presenting as corticobasal syndrome
Objective: To compare clinical features and natural course of corticobasal degeneration (CBD) presenting as corticobasal syndrome (CBD-CBS) and progressive supranuclear palsy presenting as corticobasal syndrome…Clinico-pathological Findings In Autopsy Cases With Non-Specific Glial Tauopathy
Objective: Determine Clinico-pathological correlates of aging-related tau astrogliopathy (ARTAG). Background: Aging-related tau astrogliopathy (ARTAG) appears to be a morphological spectrum of astroglial pathology mostly seen in…Differential Gene Expression in Parkinson Disease and Chronic Traumatic Encephalopathy
Objective: The research would like to determine if similar overexpressed genes between CTE and PD may explain the occurrence of parkinsonism in CTE. This was…A novel intronic variant in MAPT causes FTLD-parkinsonism: Implications for regulatory mechanism of MAPT pre-mRNA splicing
Objective: To report the identification of a novel intronic variant in MAPT in a patient with familial parkinsonism-frontotemporal lobar degeneration (FTLD). Background: MAPT mutations are…Activity of Cerebral Networks, Amyloid and Microglia in Corticobasal Syndrome: the ActiGliA study
Objective: The purpose of this prospective cohort study is to analyse the topographical and temporal relationship between cerebral microglia activity changes, network degeneration and atrophy…Clinical heterogeneity and neuropathological correlation in progressive supranuclear palsy – description of 4 cases
Objective: Description of four cases of definite PSP and assessment of the relation between clinical characteristics and severity and topographical distribution of tau pathology pathology.…Comparative Grey and White Matter Tau Pathology in LBD and PSP using Digital Histologic Measurements
Objective: To compare the regional distribution of cortical tau pathology between Lewy body disorders (LBD: Parkinson’s disease and dementia with Lewy bodies (DLB)) and progressive…
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